Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension

Abstract High blood pressure is the heritable risk factor for cardiovascular and kidney diseases. Genome-wide association studies(GWAS) on blood pressure traits increase our understanding of its underlying genetic basis. However, a large proportion of GWAS was conducted in Europeans, and some roadbl...

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Autores principales:	Goodarz Kolifarhood, Siamak Sabour, Mahdi Akbarzadeh, Bahareh Sedaghati-khayat, Kamran Guity, Saeid Rasekhi Dehkordi, Mahmoud Amiri Roudbar, Farzad Hadaegh, Fereidoun Azizi, Maryam S. Daneshpour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77b16adc5c9b449d90880e1187b18a8e
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spelling	oai:doaj.org-article:77b16adc5c9b449d90880e1187b18a8e2021-12-02T15:02:48ZGenome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension10.1038/s41598-021-90925-w2045-2322https://doaj.org/article/77b16adc5c9b449d90880e1187b18a8e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90925-whttps://doaj.org/toc/2045-2322Abstract High blood pressure is the heritable risk factor for cardiovascular and kidney diseases. Genome-wide association studies(GWAS) on blood pressure traits increase our understanding of its underlying genetic basis. However, a large proportion of GWAS was conducted in Europeans, and some roadblocks deprive other populations to benefit from their results. Iranians population with a high degree of genomic specificity has not been represented in international databases to date, so to fill the gap, we explored the effects of 652,919 genomic variants on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Hypertension (HTN) in 7694 Iranian adults aged 18 and over from Tehran Cardiometabolic Genetic Study (TCGS). We identified consistent signals on ZBED9 associated with HTN in the genome-wide borderline threshold after adjusting for different sets of environmental predictors. Moreover, strong signals on ABHD17C and suggestive signals on FBN1 were detected for DBP and SBP, respectively, while these signals were not consistent in different GWA analysis. Our finding on ZBED9 was confirmed for all BP traits by linkage analysis in an independent sample. We found significant associations with similar direction of effects and allele frequency of genetic variants on ZBED9 with DBP (genome-wide threshold) and HTN (nominal threshold) in GWAS summary data of UK Biobank. Although there is no strong evidence to support the function of ZBED9 in blood pressure regulation, it provides new insight into the pleiotropic effects of hypertension and other cardiovascular diseases.Goodarz KolifarhoodSiamak SabourMahdi AkbarzadehBahareh Sedaghati-khayatKamran GuitySaeid Rasekhi DehkordiMahmoud Amiri RoudbarFarzad HadaeghFereidoun AziziMaryam S. DaneshpourNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Goodarz Kolifarhood Siamak Sabour Mahdi Akbarzadeh Bahareh Sedaghati-khayat Kamran Guity Saeid Rasekhi Dehkordi Mahmoud Amiri Roudbar Farzad Hadaegh Fereidoun Azizi Maryam S. Daneshpour Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension
description	Abstract High blood pressure is the heritable risk factor for cardiovascular and kidney diseases. Genome-wide association studies(GWAS) on blood pressure traits increase our understanding of its underlying genetic basis. However, a large proportion of GWAS was conducted in Europeans, and some roadblocks deprive other populations to benefit from their results. Iranians population with a high degree of genomic specificity has not been represented in international databases to date, so to fill the gap, we explored the effects of 652,919 genomic variants on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Hypertension (HTN) in 7694 Iranian adults aged 18 and over from Tehran Cardiometabolic Genetic Study (TCGS). We identified consistent signals on ZBED9 associated with HTN in the genome-wide borderline threshold after adjusting for different sets of environmental predictors. Moreover, strong signals on ABHD17C and suggestive signals on FBN1 were detected for DBP and SBP, respectively, while these signals were not consistent in different GWA analysis. Our finding on ZBED9 was confirmed for all BP traits by linkage analysis in an independent sample. We found significant associations with similar direction of effects and allele frequency of genetic variants on ZBED9 with DBP (genome-wide threshold) and HTN (nominal threshold) in GWAS summary data of UK Biobank. Although there is no strong evidence to support the function of ZBED9 in blood pressure regulation, it provides new insight into the pleiotropic effects of hypertension and other cardiovascular diseases.
format	article
author	Goodarz Kolifarhood Siamak Sabour Mahdi Akbarzadeh Bahareh Sedaghati-khayat Kamran Guity Saeid Rasekhi Dehkordi Mahmoud Amiri Roudbar Farzad Hadaegh Fereidoun Azizi Maryam S. Daneshpour
author_facet	Goodarz Kolifarhood Siamak Sabour Mahdi Akbarzadeh Bahareh Sedaghati-khayat Kamran Guity Saeid Rasekhi Dehkordi Mahmoud Amiri Roudbar Farzad Hadaegh Fereidoun Azizi Maryam S. Daneshpour
author_sort	Goodarz Kolifarhood
title	Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension
title_short	Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension
title_full	Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension
title_fullStr	Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension
title_full_unstemmed	Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension
title_sort	genome-wide association study on blood pressure traits in the iranian population suggests zbed9 as a new locus for hypertension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77b16adc5c9b449d90880e1187b18a8e
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Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension

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