Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study

Tigest Getachew,1 Tadesse Hailu,2 Megbaru Alemu2 1Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia; 2Department of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Tadesse Hailu Email tadessehailu89@gmail.comBackground:...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Getachew T, Hailu T, Alemu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cryptosporidium species isospora belli antiretroviral treatment hiv/aids Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/77b1c6ce467747bba6642f897d935d45
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77b1c6ce467747bba6642f897d935d45
record_format	dspace
spelling	oai:doaj.org-article:77b1c6ce467747bba6642f897d935d452021-12-02T17:55:06ZPrevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study1179-1373https://doaj.org/article/77b1c6ce467747bba6642f897d935d452021-07-01T00:00:00Zhttps://www.dovepress.com/prevalence-of-opportunistic-intestinal-parasitic-infections-among-hiva-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Tigest Getachew,1 Tadesse Hailu,2 Megbaru Alemu2 1Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia; 2Department of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Tadesse Hailu Email tadessehailu89@gmail.comBackground: Coccidian parasites are opportunistic intestinal parasites that cause diarrhea in immunocompromised individuals. Although the impacts of coccidian infection are significant among HIV/AIDS infected cases, proper diagnosis and management of coccidian infection is limited in sub-Saharan Africa including Ethiopia.Objective: The aim of this study was to determine the prevalence of coccidian parasitic infections among HIV/AIDS cases before and after commencement of antiretroviral treatment.Methods: An institution-based longitudinal study was conducted among 304 randomly selected HIV/AIDS cases from February to July 2018 before and after commencement of antiretroviral therapy. A structured questionnaire was used to collect sociodemographic and associated factors data. Stool and blood samples were collected before and three months after treatment. Coccidian detection and CD4+ count were conducted via modified acid fast stain technique and fluorescence-activated cell scanning, respectively. Data were entered and analyzed using SPSS version 20. Descriptive statistics were used to compute coccidian prevalence. Logistic regression was used to compute possible association between associated factors and coccidian parasitic infection. Variables with P< 0.05 were considered to be statistically significant.Results: Among 304 HIV/AIDS cases, prevalence of coccidian parasitic infection before and after antiretroviral treatment was 23.4% and 8.9%, respectively. Prevalence of Cryptosporidium spp. (19.7%) and Isospora belli (4.3%) before antiretroviral treatment were higher than Cryptosporidium spp. (7.9%) and Isospora belli (1.0%) after treatment. Drinking unprotected water (AOR: 7.41; 95%CI: 1.64– 33.45), poor knowledge of HIV/AIDS and coccidian parasite (AOR: 4.19; 95%CI: 1.69– 10.40), and CD4+ count below 200 cells/mm3 (AOR: 62.49; 95%CI: 25.32– 154.21) were significantly associated with coccidian infection.Conclusion: Prevalence of coccidian parasites among HIV/AIDS cases decreases after antiretroviral treatment. Drinking unsafe water, limited knowledge of HIV/AIDS and coccidian parasite and low CD4+ cell count are factors associated with coccidian infection. Therefore, proper detection and treatment of coccidian parasites among HIV/AIDS cases should be prioritized.Keywords: Cryptosporidium spp., Isospora belli, antiretroviral treatment, HIV/AIDSGetachew THailu TAlemu MDove Medical Pressarticlecryptosporidium speciesisospora belliantiretroviral treatmenthiv/aidsImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 767-774 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cryptosporidium species isospora belli antiretroviral treatment hiv/aids Immunologic diseases. Allergy RC581-607
spellingShingle	cryptosporidium species isospora belli antiretroviral treatment hiv/aids Immunologic diseases. Allergy RC581-607 Getachew T Hailu T Alemu M Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study
description	Tigest Getachew,1 Tadesse Hailu,2 Megbaru Alemu2 1Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia; 2Department of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Tadesse Hailu Email tadessehailu89@gmail.comBackground: Coccidian parasites are opportunistic intestinal parasites that cause diarrhea in immunocompromised individuals. Although the impacts of coccidian infection are significant among HIV/AIDS infected cases, proper diagnosis and management of coccidian infection is limited in sub-Saharan Africa including Ethiopia.Objective: The aim of this study was to determine the prevalence of coccidian parasitic infections among HIV/AIDS cases before and after commencement of antiretroviral treatment.Methods: An institution-based longitudinal study was conducted among 304 randomly selected HIV/AIDS cases from February to July 2018 before and after commencement of antiretroviral therapy. A structured questionnaire was used to collect sociodemographic and associated factors data. Stool and blood samples were collected before and three months after treatment. Coccidian detection and CD4+ count were conducted via modified acid fast stain technique and fluorescence-activated cell scanning, respectively. Data were entered and analyzed using SPSS version 20. Descriptive statistics were used to compute coccidian prevalence. Logistic regression was used to compute possible association between associated factors and coccidian parasitic infection. Variables with P< 0.05 were considered to be statistically significant.Results: Among 304 HIV/AIDS cases, prevalence of coccidian parasitic infection before and after antiretroviral treatment was 23.4% and 8.9%, respectively. Prevalence of Cryptosporidium spp. (19.7%) and Isospora belli (4.3%) before antiretroviral treatment were higher than Cryptosporidium spp. (7.9%) and Isospora belli (1.0%) after treatment. Drinking unprotected water (AOR: 7.41; 95%CI: 1.64– 33.45), poor knowledge of HIV/AIDS and coccidian parasite (AOR: 4.19; 95%CI: 1.69– 10.40), and CD4+ count below 200 cells/mm3 (AOR: 62.49; 95%CI: 25.32– 154.21) were significantly associated with coccidian infection.Conclusion: Prevalence of coccidian parasites among HIV/AIDS cases decreases after antiretroviral treatment. Drinking unsafe water, limited knowledge of HIV/AIDS and coccidian parasite and low CD4+ cell count are factors associated with coccidian infection. Therefore, proper detection and treatment of coccidian parasites among HIV/AIDS cases should be prioritized.Keywords: Cryptosporidium spp., Isospora belli, antiretroviral treatment, HIV/AIDS
format	article
author	Getachew T Hailu T Alemu M
author_facet	Getachew T Hailu T Alemu M
author_sort	Getachew T
title	Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study
title_short	Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study
title_full	Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study
title_fullStr	Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study
title_full_unstemmed	Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study
title_sort	prevalence of opportunistic intestinal parasitic infections among hiv/aids patients before and after commencement of antiretroviral treatment at felege hiwot referral hospital: a follow-up study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/77b1c6ce467747bba6642f897d935d45
work_keys_str_mv	AT getachewt prevalenceofopportunisticintestinalparasiticinfectionsamonghivaidspatientsbeforeandaftercommencementofantiretroviraltreatmentatfelegehiwotreferralhospitalafollowupstudy AT hailut prevalenceofopportunisticintestinalparasiticinfectionsamonghivaidspatientsbeforeandaftercommencementofantiretroviraltreatmentatfelegehiwotreferralhospitalafollowupstudy AT alemum prevalenceofopportunisticintestinalparasiticinfectionsamonghivaidspatientsbeforeandaftercommencementofantiretroviraltreatmentatfelegehiwotreferralhospitalafollowupstudy
_version_	1718379115470389248

Prevalence of Opportunistic Intestinal Parasitic Infections Among HIV/AIDS Patients Before and After Commencement of Antiretroviral Treatment at Felege Hiwot Referral Hospital: A Follow-up Study

Ejemplares similares