Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.

<h4>Background</h4>Heterotopic ossification (HO) is a frequent complication after central nervous system (CNS) damage but has seldom been studied. We aimed to investigate features of HO for the first time in a large sample and the rate of early recurrence of HO in terms of the time of su...

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Autores principales:	François Genêt, Claire Jourdan, Alexis Schnitzler, Christine Lautridou, Didier Guillemot, Thierry Judet, Serge Poiraudeau, Philippe Denormandie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77b27fb62f624f6e8265c84cf80f155a
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spelling	oai:doaj.org-article:77b27fb62f624f6e8265c84cf80f155a2021-11-18T06:59:26ZTroublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.1932-620310.1371/journal.pone.0016632https://doaj.org/article/77b27fb62f624f6e8265c84cf80f155a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21304993/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Heterotopic ossification (HO) is a frequent complication after central nervous system (CNS) damage but has seldom been studied. We aimed to investigate features of HO for the first time in a large sample and the rate of early recurrence of HO in terms of the time of surgery.<h4>Methodology/principal findings</h4>We retrospectively analyzed data from an anonymous prospective survey of patients undergoing surgery between May 1993 and November 2009 in our institution for troublesome HO related to acquired neurological disease. Demographic and HO characteristics and neurological etiologies were recorded. For 357 consecutive patients, we collected data on 539 first surgeries for HO (129 surgeries for multiple sites). During the follow-up, recurrences requiring another surgery appeared in 31 cases (5.8% [31/539]; 95% confidence interval [CI]: 3.8%-7.8%; 27 patients). Most HO requiring surgery occurred after traumatic brain injury (199 patients [55.7%]), then spinal cord injury (86 [24.0%]), stroke (42 [11.8%]) and cerebral anoxia (30 [8.6%]). The hip was the primary site of HO (328 [60.9%]), then the elbow (115 [21.3%]), knee (77 [14.3%]) and shoulder (19 [3.5%]). For all patients, 181 of the surgeries were performed within the first year after the CNS damage, without recurrence of HO. Recurrence was not associated with etiology (p = 0.46), sex (p = 1.00), age at CNS damage (p = 0.2), multisite localization (p = 0.34), or delay to surgery (p = 0.7).<h4>Conclusions/significance</h4>In patients with CNS damage, troublesome HO and recurrence occurs most frequently after traumatic brain injury and appears frequently in the hip and elbow. Early surgery for HO is not a factor of recurrence.François GenêtClaire JourdanAlexis SchnitzlerChristine LautridouDidier GuillemotThierry JudetSerge PoiraudeauPhilippe DenormandiePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16632 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q François Genêt Claire Jourdan Alexis Schnitzler Christine Lautridou Didier Guillemot Thierry Judet Serge Poiraudeau Philippe Denormandie Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
description	<h4>Background</h4>Heterotopic ossification (HO) is a frequent complication after central nervous system (CNS) damage but has seldom been studied. We aimed to investigate features of HO for the first time in a large sample and the rate of early recurrence of HO in terms of the time of surgery.<h4>Methodology/principal findings</h4>We retrospectively analyzed data from an anonymous prospective survey of patients undergoing surgery between May 1993 and November 2009 in our institution for troublesome HO related to acquired neurological disease. Demographic and HO characteristics and neurological etiologies were recorded. For 357 consecutive patients, we collected data on 539 first surgeries for HO (129 surgeries for multiple sites). During the follow-up, recurrences requiring another surgery appeared in 31 cases (5.8% [31/539]; 95% confidence interval [CI]: 3.8%-7.8%; 27 patients). Most HO requiring surgery occurred after traumatic brain injury (199 patients [55.7%]), then spinal cord injury (86 [24.0%]), stroke (42 [11.8%]) and cerebral anoxia (30 [8.6%]). The hip was the primary site of HO (328 [60.9%]), then the elbow (115 [21.3%]), knee (77 [14.3%]) and shoulder (19 [3.5%]). For all patients, 181 of the surgeries were performed within the first year after the CNS damage, without recurrence of HO. Recurrence was not associated with etiology (p = 0.46), sex (p = 1.00), age at CNS damage (p = 0.2), multisite localization (p = 0.34), or delay to surgery (p = 0.7).<h4>Conclusions/significance</h4>In patients with CNS damage, troublesome HO and recurrence occurs most frequently after traumatic brain injury and appears frequently in the hip and elbow. Early surgery for HO is not a factor of recurrence.
format	article
author	François Genêt Claire Jourdan Alexis Schnitzler Christine Lautridou Didier Guillemot Thierry Judet Serge Poiraudeau Philippe Denormandie
author_facet	François Genêt Claire Jourdan Alexis Schnitzler Christine Lautridou Didier Guillemot Thierry Judet Serge Poiraudeau Philippe Denormandie
author_sort	François Genêt
title	Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
title_short	Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
title_full	Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
title_fullStr	Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
title_full_unstemmed	Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
title_sort	troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/77b27fb62f624f6e8265c84cf80f155a
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Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries.

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