In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Abstract Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent RNA polymerase (RdR...

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Autores principales: Salvatore Ferla, Natalie E. Netzler, Sebastiano Ferla, Sofia Veronese, Daniel Enosi Tuipulotu, Salvatore Guccione, Andrea Brancale, Peter A. White, Marcella Bassetto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/77b2d570609640eb84832ed1a696b6b2
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