A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization

Synthetic organic fluorophores are powerful tools for bioimaging, but frequently display shortened observation times and signal fluctuations. Here, the authors report a general method to covalently label a biomolecule with a fluorophore and photostabilizer, reducing unwanted photophysical effects by...

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Autores principales:	Jasper H. M. van der Velde, Jens Oelerich, Jingyi Huang, Jochem H. Smit, Atieh Aminian Jazi, Silvia Galiani, Kirill Kolmakov, Giorgos Gouridis, Christian Eggeling, Andreas Herrmann, Gerard Roelfes, Thorben Cordes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77b60fed403541aa9d01f52a52fbdb39
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spelling	oai:doaj.org-article:77b60fed403541aa9d01f52a52fbdb392021-12-02T14:40:14ZA simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization10.1038/ncomms101442041-1723https://doaj.org/article/77b60fed403541aa9d01f52a52fbdb392016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10144https://doaj.org/toc/2041-1723Synthetic organic fluorophores are powerful tools for bioimaging, but frequently display shortened observation times and signal fluctuations. Here, the authors report a general method to covalently label a biomolecule with a fluorophore and photostabilizer, reducing unwanted photophysical effects by intramolecular quenching of reactive fluorophore states.Jasper H. M. van der VeldeJens OelerichJingyi HuangJochem H. SmitAtieh Aminian JaziSilvia GalianiKirill KolmakovGiorgos GouridisChristian EggelingAndreas HerrmannGerard RoelfesThorben CordesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jasper H. M. van der Velde Jens Oelerich Jingyi Huang Jochem H. Smit Atieh Aminian Jazi Silvia Galiani Kirill Kolmakov Giorgos Gouridis Christian Eggeling Andreas Herrmann Gerard Roelfes Thorben Cordes A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
description	Synthetic organic fluorophores are powerful tools for bioimaging, but frequently display shortened observation times and signal fluctuations. Here, the authors report a general method to covalently label a biomolecule with a fluorophore and photostabilizer, reducing unwanted photophysical effects by intramolecular quenching of reactive fluorophore states.
format	article
author	Jasper H. M. van der Velde Jens Oelerich Jingyi Huang Jochem H. Smit Atieh Aminian Jazi Silvia Galiani Kirill Kolmakov Giorgos Gouridis Christian Eggeling Andreas Herrmann Gerard Roelfes Thorben Cordes
author_facet	Jasper H. M. van der Velde Jens Oelerich Jingyi Huang Jochem H. Smit Atieh Aminian Jazi Silvia Galiani Kirill Kolmakov Giorgos Gouridis Christian Eggeling Andreas Herrmann Gerard Roelfes Thorben Cordes
author_sort	Jasper H. M. van der Velde
title	A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
title_short	A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
title_full	A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
title_fullStr	A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
title_full_unstemmed	A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
title_sort	simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/77b60fed403541aa9d01f52a52fbdb39
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A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization

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