Pathology of Puumala hantavirus infection in macaques.

Hantaviruses are globally important human pathogens that cause hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Capillary leakage is central to hantaviral diseases, but how it develops, has remained unknown. It has been hypothesized that the pathogenesis of hantavirus infecti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tarja Sironen, Jonas Klingström, Antti Vaheri, Leif C Andersson, Ake Lundkvist, Alexander Plyusnin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77bca9295f964cc084aacca982efcffb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77bca9295f964cc084aacca982efcffb
record_format	dspace
spelling	oai:doaj.org-article:77bca9295f964cc084aacca982efcffb2021-11-25T06:18:54ZPathology of Puumala hantavirus infection in macaques.1932-620310.1371/journal.pone.0003035https://doaj.org/article/77bca9295f964cc084aacca982efcffb2008-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18716663/?tool=EBIhttps://doaj.org/toc/1932-6203Hantaviruses are globally important human pathogens that cause hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Capillary leakage is central to hantaviral diseases, but how it develops, has remained unknown. It has been hypothesized that the pathogenesis of hantavirus infection would be a complex interplay between direct viral effects and immunopathological mechanisms. Both of these were studied in the so far best model of mild hemorrhagic fever with renal syndrome, i.e. cynomolgus macaques infected with wild-type Puumala hantavirus. Viral RNA detected by in situ hybridization and nucleocapsid protein detected by immunohistochemical staining were observed in kidney, spleen and liver tissues. Inflammatory cell infiltrations and tubular damage were found in the kidneys, and these infiltrations contained mainly CD8-type T-cells. Importantly, these results are consistent with those obtained from patients with hantaviral disease, thus showing that the macaque model of hantavirus infection mimics human infection also on the tissue level. Furthermore, both the markers of viral replication and the T-cells appeared to co-localize in the kidneys to the sites of tissue damage, suggesting that these two together might be responsible for the pathogenesis of hantavirus infection.Tarja SironenJonas KlingströmAntti VaheriLeif C AnderssonAke LundkvistAlexander PlyusninPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 8, p e3035 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tarja Sironen Jonas Klingström Antti Vaheri Leif C Andersson Ake Lundkvist Alexander Plyusnin Pathology of Puumala hantavirus infection in macaques.
description	Hantaviruses are globally important human pathogens that cause hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Capillary leakage is central to hantaviral diseases, but how it develops, has remained unknown. It has been hypothesized that the pathogenesis of hantavirus infection would be a complex interplay between direct viral effects and immunopathological mechanisms. Both of these were studied in the so far best model of mild hemorrhagic fever with renal syndrome, i.e. cynomolgus macaques infected with wild-type Puumala hantavirus. Viral RNA detected by in situ hybridization and nucleocapsid protein detected by immunohistochemical staining were observed in kidney, spleen and liver tissues. Inflammatory cell infiltrations and tubular damage were found in the kidneys, and these infiltrations contained mainly CD8-type T-cells. Importantly, these results are consistent with those obtained from patients with hantaviral disease, thus showing that the macaque model of hantavirus infection mimics human infection also on the tissue level. Furthermore, both the markers of viral replication and the T-cells appeared to co-localize in the kidneys to the sites of tissue damage, suggesting that these two together might be responsible for the pathogenesis of hantavirus infection.
format	article
author	Tarja Sironen Jonas Klingström Antti Vaheri Leif C Andersson Ake Lundkvist Alexander Plyusnin
author_facet	Tarja Sironen Jonas Klingström Antti Vaheri Leif C Andersson Ake Lundkvist Alexander Plyusnin
author_sort	Tarja Sironen
title	Pathology of Puumala hantavirus infection in macaques.
title_short	Pathology of Puumala hantavirus infection in macaques.
title_full	Pathology of Puumala hantavirus infection in macaques.
title_fullStr	Pathology of Puumala hantavirus infection in macaques.
title_full_unstemmed	Pathology of Puumala hantavirus infection in macaques.
title_sort	pathology of puumala hantavirus infection in macaques.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/77bca9295f964cc084aacca982efcffb
work_keys_str_mv	AT tarjasironen pathologyofpuumalahantavirusinfectioninmacaques AT jonasklingstrom pathologyofpuumalahantavirusinfectioninmacaques AT anttivaheri pathologyofpuumalahantavirusinfectioninmacaques AT leifcandersson pathologyofpuumalahantavirusinfectioninmacaques AT akelundkvist pathologyofpuumalahantavirusinfectioninmacaques AT alexanderplyusnin pathologyofpuumalahantavirusinfectioninmacaques
_version_	1718413932009357312

Pathology of Puumala hantavirus infection in macaques.

Ejemplares similares