DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES

Objective: To determine the diagnostic accuracy of immunoassays in drug screening as required in emergency for the rapid diagnosis of drug intoxication in travel related crimes. Study Design: Diagnostic accuracy study. Place and Duration of Study: department of Chemical Pathology and Endocrino...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sadia Dawood, Ayesha Hafeez, Aamir Ijaz, Summera Moeen, Asif Ali Memon, Sumaira Mubarik
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	drug facilitated crimes drug screening immunoassay diagnostic accuracy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/77bd1bccd133486f8870de4fd4668fe5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77bd1bccd133486f8870de4fd4668fe5
record_format	dspace
spelling	oai:doaj.org-article:77bd1bccd133486f8870de4fd4668fe52021-12-02T17:10:37ZDIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES0030-96482411-884210.51253/pafmj.v71i1.3167https://doaj.org/article/77bd1bccd133486f8870de4fd4668fe52021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3167https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the diagnostic accuracy of immunoassays in drug screening as required in emergency for the rapid diagnosis of drug intoxication in travel related crimes. Study Design: Diagnostic accuracy study. Place and Duration of Study: department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Jul 2017 to Jun 2018. Methodology: Sealed urine specimens of 77 patients with history of suspected intoxication in drugs facilitated street crimes, received for toxicology screening were included in the study. All the specimens were analysed, initially on immunoassay (index test) and then on Triple Quadrupole Liquid chromatography–Mass spectrometry (reference standard). Benzodiazepine being the main class of drugs involved in travel related crimes, diagnostic accuracy of immunoassay technique was assessed for these by calculating its sensitivity, specificity, positive predictive value and negative predictive value. Results: Victims were predominantly males and public transportation was the most common mode of transport. The most commonly used drug was Lorazepam. Immunoassay failed to detect few cases who were shown to be intoxicated with benzodiazepines by liquid-chromatography tandem mass spectrometry. The false negative rate was 4.9%. Only one false positive case was observed. The accuracy was calculated to be 94.8% with sensitivity of 95.08% and specificity of 93.7%. Conclusion: Immunoassay was found reliable for rapid testing in drug facilitated intoxication cases. However critical decision making should be done cautiously keeping in mind the limitations associated with these screening procedures.Sadia DawoodAyesha HafeezAamir IjazSummera MoeenAsif Ali MemonSumaira MubarikArmy Medical College Rawalpindiarticledrug facilitated crimesdrug screeningimmunoassaydiagnostic accuracyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 101-06 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug facilitated crimes drug screening immunoassay diagnostic accuracy Medicine R Medicine (General) R5-920
spellingShingle	drug facilitated crimes drug screening immunoassay diagnostic accuracy Medicine R Medicine (General) R5-920 Sadia Dawood Ayesha Hafeez Aamir Ijaz Summera Moeen Asif Ali Memon Sumaira Mubarik DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES
description	Objective: To determine the diagnostic accuracy of immunoassays in drug screening as required in emergency for the rapid diagnosis of drug intoxication in travel related crimes. Study Design: Diagnostic accuracy study. Place and Duration of Study: department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Jul 2017 to Jun 2018. Methodology: Sealed urine specimens of 77 patients with history of suspected intoxication in drugs facilitated street crimes, received for toxicology screening were included in the study. All the specimens were analysed, initially on immunoassay (index test) and then on Triple Quadrupole Liquid chromatography–Mass spectrometry (reference standard). Benzodiazepine being the main class of drugs involved in travel related crimes, diagnostic accuracy of immunoassay technique was assessed for these by calculating its sensitivity, specificity, positive predictive value and negative predictive value. Results: Victims were predominantly males and public transportation was the most common mode of transport. The most commonly used drug was Lorazepam. Immunoassay failed to detect few cases who were shown to be intoxicated with benzodiazepines by liquid-chromatography tandem mass spectrometry. The false negative rate was 4.9%. Only one false positive case was observed. The accuracy was calculated to be 94.8% with sensitivity of 95.08% and specificity of 93.7%. Conclusion: Immunoassay was found reliable for rapid testing in drug facilitated intoxication cases. However critical decision making should be done cautiously keeping in mind the limitations associated with these screening procedures.
format	article
author	Sadia Dawood Ayesha Hafeez Aamir Ijaz Summera Moeen Asif Ali Memon Sumaira Mubarik
author_facet	Sadia Dawood Ayesha Hafeez Aamir Ijaz Summera Moeen Asif Ali Memon Sumaira Mubarik
author_sort	Sadia Dawood
title	DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES
title_short	DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES
title_full	DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES
title_fullStr	DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES
title_full_unstemmed	DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES
title_sort	diagnostic accuracy of drug screening immunoassays in drug facilitated crimes
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/77bd1bccd133486f8870de4fd4668fe5
work_keys_str_mv	AT sadiadawood diagnosticaccuracyofdrugscreeningimmunoassaysindrugfacilitatedcrimes AT ayeshahafeez diagnosticaccuracyofdrugscreeningimmunoassaysindrugfacilitatedcrimes AT aamirijaz diagnosticaccuracyofdrugscreeningimmunoassaysindrugfacilitatedcrimes AT summeramoeen diagnosticaccuracyofdrugscreeningimmunoassaysindrugfacilitatedcrimes AT asifalimemon diagnosticaccuracyofdrugscreeningimmunoassaysindrugfacilitatedcrimes AT sumairamubarik diagnosticaccuracyofdrugscreeningimmunoassaysindrugfacilitatedcrimes
_version_	1718381504720011264

DIAGNOSTIC ACCURACY OF DRUG SCREENING IMMUNOASSAYS IN DRUG FACILITATED CRIMES

Ejemplares similares