HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology

In silico models of cells can provide insight into the causes and effects of disease states and reduce the need for in vivo studies. Here, the authors present a kinetic model of hepatocyte metabolism including energy, carbohydrate, lipid and nitrogen metabolism and hormonal and allosteric regulation...

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Autores principales:	Nikolaus Berndt, Sascha Bulik, Iwona Wallach, Tilo Wünsch, Matthias König, Martin Stockmann, David Meierhofer, Hermann-Georg Holzhütter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77be495539204df281e2112ebf72702b
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spelling	oai:doaj.org-article:77be495539204df281e2112ebf72702b2021-12-02T16:49:32ZHEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology10.1038/s41467-018-04720-92041-1723https://doaj.org/article/77be495539204df281e2112ebf72702b2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04720-9https://doaj.org/toc/2041-1723In silico models of cells can provide insight into the causes and effects of disease states and reduce the need for in vivo studies. Here, the authors present a kinetic model of hepatocyte metabolism including energy, carbohydrate, lipid and nitrogen metabolism and hormonal and allosteric regulation of enzymatic activity.Nikolaus BerndtSascha BulikIwona WallachTilo WünschMatthias KönigMartin StockmannDavid MeierhoferHermann-Georg HolzhütterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolaus Berndt Sascha Bulik Iwona Wallach Tilo Wünsch Matthias König Martin Stockmann David Meierhofer Hermann-Georg Holzhütter HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
description	In silico models of cells can provide insight into the causes and effects of disease states and reduce the need for in vivo studies. Here, the authors present a kinetic model of hepatocyte metabolism including energy, carbohydrate, lipid and nitrogen metabolism and hormonal and allosteric regulation of enzymatic activity.
format	article
author	Nikolaus Berndt Sascha Bulik Iwona Wallach Tilo Wünsch Matthias König Martin Stockmann David Meierhofer Hermann-Georg Holzhütter
author_facet	Nikolaus Berndt Sascha Bulik Iwona Wallach Tilo Wünsch Matthias König Martin Stockmann David Meierhofer Hermann-Georg Holzhütter
author_sort	Nikolaus Berndt
title	HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
title_short	HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
title_full	HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
title_fullStr	HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
title_full_unstemmed	HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
title_sort	hepatokin1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/77be495539204df281e2112ebf72702b
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HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology

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