The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review

<h4>Background</h4> A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection. <h4>Object...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Natasha Marcella Vaselli, Daniel Hungerford, Ben Shenton, Arwa Khashkhusha, Nigel A. Cunliffe, Neil French
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77beb901365d467ab6ad9987c1e8017e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77beb901365d467ab6ad9987c1e8017e
record_format	dspace
spelling	oai:doaj.org-article:77beb901365d467ab6ad9987c1e8017e2021-11-11T06:44:20ZThe seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review1932-6203https://doaj.org/article/77beb901365d467ab6ad9987c1e8017e2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562786/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection. <h4>Objectives</h4> This systematic review of SARS-CoV-2 seroprevalence studies in Europe was undertaken to inform public health strategies including vaccination, that aim to accelerate population immunity. <h4>Methods</h4> We searched the databases Web of Science, MEDLINE, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews and grey literature sources for studies reporting seroprevalence of SARS-CoV-2 antibodies in Europe published between 01/12/2019–30/09/20. We provide a narrative synthesis of included studies. Studies were categorized into subgroups including healthcare workers (HCWs), community, outbreaks, pregnancy and children/school. Due to heterogeneity in other subgroups, we only performed a random effects meta-analysis of the seroprevalence amongst HCWs stratified by their country. <h4>Results</h4> 115 studies were included spanning 17 European countries, that estimated the seroprevalence of SARS-CoV-2 from samples obtained between November 2019 –August 2020. A total of 54/115 studies included HCWs with a reported seroprevalence among HCWs ranging from 0.7% to 45.3%, which did not differ significantly by country. In community studies significant heterogeneity was reported in the seroprevalence between different age groups and the majority of studies reported there was no significant difference by gender. <h4>Conclusion</h4> This review demonstrates a wide heterogeneity in reported seroprevalence of SARS-CoV-2 antibodies between populations. Continued evaluation of seroprevalence is required to understand the impact of public health measures and inform interventions including vaccination programmes.Natasha Marcella VaselliDaniel HungerfordBen ShentonArwa KhashkhushaNigel A. CunliffeNeil FrenchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natasha Marcella Vaselli Daniel Hungerford Ben Shenton Arwa Khashkhusha Nigel A. Cunliffe Neil French The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
description	<h4>Background</h4> A year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection. <h4>Objectives</h4> This systematic review of SARS-CoV-2 seroprevalence studies in Europe was undertaken to inform public health strategies including vaccination, that aim to accelerate population immunity. <h4>Methods</h4> We searched the databases Web of Science, MEDLINE, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews and grey literature sources for studies reporting seroprevalence of SARS-CoV-2 antibodies in Europe published between 01/12/2019–30/09/20. We provide a narrative synthesis of included studies. Studies were categorized into subgroups including healthcare workers (HCWs), community, outbreaks, pregnancy and children/school. Due to heterogeneity in other subgroups, we only performed a random effects meta-analysis of the seroprevalence amongst HCWs stratified by their country. <h4>Results</h4> 115 studies were included spanning 17 European countries, that estimated the seroprevalence of SARS-CoV-2 from samples obtained between November 2019 –August 2020. A total of 54/115 studies included HCWs with a reported seroprevalence among HCWs ranging from 0.7% to 45.3%, which did not differ significantly by country. In community studies significant heterogeneity was reported in the seroprevalence between different age groups and the majority of studies reported there was no significant difference by gender. <h4>Conclusion</h4> This review demonstrates a wide heterogeneity in reported seroprevalence of SARS-CoV-2 antibodies between populations. Continued evaluation of seroprevalence is required to understand the impact of public health measures and inform interventions including vaccination programmes.
format	article
author	Natasha Marcella Vaselli Daniel Hungerford Ben Shenton Arwa Khashkhusha Nigel A. Cunliffe Neil French
author_facet	Natasha Marcella Vaselli Daniel Hungerford Ben Shenton Arwa Khashkhusha Nigel A. Cunliffe Neil French
author_sort	Natasha Marcella Vaselli
title	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
title_short	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
title_full	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
title_fullStr	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
title_full_unstemmed	The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review
title_sort	seroprevalence of sars-cov-2 during the first wave in europe 2020: a systematic review
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/77beb901365d467ab6ad9987c1e8017e
work_keys_str_mv	AT natashamarcellavaselli theseroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT danielhungerford theseroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT benshenton theseroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT arwakhashkhusha theseroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT nigelacunliffe theseroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT neilfrench theseroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT natashamarcellavaselli seroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT danielhungerford seroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT benshenton seroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT arwakhashkhusha seroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT nigelacunliffe seroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview AT neilfrench seroprevalenceofsarscov2duringthefirstwaveineurope2020asystematicreview
_version_	1718439503601860608

The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review

Ejemplares similares