Structural basis of ion transport and inhibition in ferroportin

Ferroportin is an iron exporter essential for releasing cellular iron into circulation and is inhibited by a peptide hormone, hepcidin. Here authors present cryo-EM structures of the ferroportin from the primate Philippine tarsier (TsFpn) with and without hepcidin and show that TsFpn is an electrone...

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Autores principales:	Yaping Pan, Zhenning Ren, Shuai Gao, Jiemin Shen, Lie Wang, Zhichun Xu, Ye Yu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77c24e64d4fc4521bced656e46273ab5
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spelling	oai:doaj.org-article:77c24e64d4fc4521bced656e46273ab52021-12-02T14:40:27ZStructural basis of ion transport and inhibition in ferroportin10.1038/s41467-020-19458-62041-1723https://doaj.org/article/77c24e64d4fc4521bced656e46273ab52020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19458-6https://doaj.org/toc/2041-1723Ferroportin is an iron exporter essential for releasing cellular iron into circulation and is inhibited by a peptide hormone, hepcidin. Here authors present cryo-EM structures of the ferroportin from the primate Philippine tarsier (TsFpn) with and without hepcidin and show that TsFpn is an electroneutral H+ /Fe2+ antiporter.Yaping PanZhenning RenShuai GaoJiemin ShenLie WangZhichun XuYe YuPreetham BachinaHanzhi ZhangXiao FanArthur LaganowskyNieng YanMing ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaping Pan Zhenning Ren Shuai Gao Jiemin Shen Lie Wang Zhichun Xu Ye Yu Preetham Bachina Hanzhi Zhang Xiao Fan Arthur Laganowsky Nieng Yan Ming Zhou Structural basis of ion transport and inhibition in ferroportin
description	Ferroportin is an iron exporter essential for releasing cellular iron into circulation and is inhibited by a peptide hormone, hepcidin. Here authors present cryo-EM structures of the ferroportin from the primate Philippine tarsier (TsFpn) with and without hepcidin and show that TsFpn is an electroneutral H+ /Fe2+ antiporter.
format	article
author	Yaping Pan Zhenning Ren Shuai Gao Jiemin Shen Lie Wang Zhichun Xu Ye Yu Preetham Bachina Hanzhi Zhang Xiao Fan Arthur Laganowsky Nieng Yan Ming Zhou
author_facet	Yaping Pan Zhenning Ren Shuai Gao Jiemin Shen Lie Wang Zhichun Xu Ye Yu Preetham Bachina Hanzhi Zhang Xiao Fan Arthur Laganowsky Nieng Yan Ming Zhou
author_sort	Yaping Pan
title	Structural basis of ion transport and inhibition in ferroportin
title_short	Structural basis of ion transport and inhibition in ferroportin
title_full	Structural basis of ion transport and inhibition in ferroportin
title_fullStr	Structural basis of ion transport and inhibition in ferroportin
title_full_unstemmed	Structural basis of ion transport and inhibition in ferroportin
title_sort	structural basis of ion transport and inhibition in ferroportin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/77c24e64d4fc4521bced656e46273ab5
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_version_	1718390303588614144

Structural basis of ion transport and inhibition in ferroportin

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