Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>

Phytoene is a colourless natural carotenoid that absorbs UV light and provides antioxidant and anti-inflammatory activities as well as protection against photodamage. It is therefore valued for its skin health and aesthetic benefits by the cosmetic industry, as well as by the health food sector. The...

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Autores principales:	Yanan Xu, Patricia J. Harvey
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	phytoene <i>Dunaliella salina</i> mitosis inhibitors herbicides red light Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/77c42300c06748b88b083a7c7c54ce2e
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spelling	oai:doaj.org-article:77c42300c06748b88b083a7c7c54ce2e2021-11-25T18:12:41ZMitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>10.3390/md191105951660-3397https://doaj.org/article/77c42300c06748b88b083a7c7c54ce2e2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/595https://doaj.org/toc/1660-3397Phytoene is a colourless natural carotenoid that absorbs UV light and provides antioxidant and anti-inflammatory activities as well as protection against photodamage. It is therefore valued for its skin health and aesthetic benefits by the cosmetic industry, as well as by the health food sector. The halotolerant green microalga <i>Dunaliella salina</i> is one of the richest sources of natural carotenoids. We have previously investigated the over-production of phytoene in <i>D. salina</i> after cultivation with the well-characterised mitosis inhibitor, chlorpropham. In this study, 15 herbicides with different modes of action were tested for their potential to promote phytoene accumulation. All herbicides showed different levels of capabilities to support phytoene over-production in <i>D. salina</i>. Most significantly, the two mitosis inhibitors tested in this study, propyzamide and chlorpropham, showed similar capacities to support the over-production of phytoene by <i>D. salina</i> cultures as phytoene desaturase inhibitors. The cellular content of phytoene increased by over 10-fold within 48 h of treatment with the mitosis inhibitors compared to untreated cultures. Results indicate a general effect of mitosis inhibitors on phytoene accumulation in <i>D. salina</i>. Furthermore, red light was found to significantly enhance the phytoene yield when used in combination with effective inhibitor treatments. Red light can be applied to maximize the production of phytoene from <i>D. salina</i>.Yanan XuPatricia J. HarveyMDPI AGarticlephytoene<i>Dunaliella salina</i>mitosis inhibitorsherbicidesred lightBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 595, p 595 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phytoene <i>Dunaliella salina</i> mitosis inhibitors herbicides red light Biology (General) QH301-705.5
spellingShingle	phytoene <i>Dunaliella salina</i> mitosis inhibitors herbicides red light Biology (General) QH301-705.5 Yanan Xu Patricia J. Harvey Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>
description	Phytoene is a colourless natural carotenoid that absorbs UV light and provides antioxidant and anti-inflammatory activities as well as protection against photodamage. It is therefore valued for its skin health and aesthetic benefits by the cosmetic industry, as well as by the health food sector. The halotolerant green microalga <i>Dunaliella salina</i> is one of the richest sources of natural carotenoids. We have previously investigated the over-production of phytoene in <i>D. salina</i> after cultivation with the well-characterised mitosis inhibitor, chlorpropham. In this study, 15 herbicides with different modes of action were tested for their potential to promote phytoene accumulation. All herbicides showed different levels of capabilities to support phytoene over-production in <i>D. salina</i>. Most significantly, the two mitosis inhibitors tested in this study, propyzamide and chlorpropham, showed similar capacities to support the over-production of phytoene by <i>D. salina</i> cultures as phytoene desaturase inhibitors. The cellular content of phytoene increased by over 10-fold within 48 h of treatment with the mitosis inhibitors compared to untreated cultures. Results indicate a general effect of mitosis inhibitors on phytoene accumulation in <i>D. salina</i>. Furthermore, red light was found to significantly enhance the phytoene yield when used in combination with effective inhibitor treatments. Red light can be applied to maximize the production of phytoene from <i>D. salina</i>.
format	article
author	Yanan Xu Patricia J. Harvey
author_facet	Yanan Xu Patricia J. Harvey
author_sort	Yanan Xu
title	Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>
title_short	Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>
title_full	Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>
title_fullStr	Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>
title_full_unstemmed	Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>
title_sort	mitosis inhibitors induce massive accumulation of phytoene in the microalga <i>dunaliella salina</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/77c42300c06748b88b083a7c7c54ce2e
work_keys_str_mv	AT yananxu mitosisinhibitorsinducemassiveaccumulationofphytoeneinthemicroalgaidunaliellasalinai AT patriciajharvey mitosisinhibitorsinducemassiveaccumulationofphytoeneinthemicroalgaidunaliellasalinai
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Mitosis Inhibitors Induce Massive Accumulation of Phytoene in the Microalga <i>Dunaliella salina</i>

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