Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats

BACKGROUND AND OBJECTIVE: Diabetes mellitus in long-term accompanies with inappropriate complications like retinopathy and neuropathy and increased pain sensation due to neuropathy. Since there is some evidence on protective and antidiabetic effects of Vaccinium myrtillus (VM), this study was design...

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Autores principales:	M Roghani, T Baluchnejadmojarad
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	vaccinium myrtillus diabetes mellitus hyperalgesia Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/77c5642f31124c13b54efd7eb59e0232
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spelling	oai:doaj.org-article:77c5642f31124c13b54efd7eb59e02322021-11-10T08:56:34ZAntinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats1561-41072251-7170https://doaj.org/article/77c5642f31124c13b54efd7eb59e02322011-05-01T00:00:00Zhttp://jbums.org/article-1-3799-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Diabetes mellitus in long-term accompanies with inappropriate complications like retinopathy and neuropathy and increased pain sensation due to neuropathy. Since there is some evidence on protective and antidiabetic effects of Vaccinium myrtillus (VM), this study was designed to investigate the antinociceptive effect of Vaccinium myrtillus (VM) in streptozotocin-diabetic rats using formalin test and hot tail immersion tests.METHODS: In this experimental study, male rats were divided into equal-sized control, VM-treated control, diabetic, sodium salicylate (SS)-treated diabetic, and VM-treated diabetic groups. For induction of diabetes, streptozotocin at a dose of 60 mg/kg (i.p) was injected. The treatment groups received oral administration of VM-mixed pelleted food (5%) for 6 weeks with no limitation. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests.FINDINGS: VM treatment of diabetic rats reduced pain score in chronic phase up to 17.9% (p<0.05). Meanwhile, SS administration significantly reduced pain score at chronic phase of the test up to 23.6% (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant 37.4% reduction in tail flick latency as compared to control ones (p<0.05). Although VM treatment of diabetic rats increased this latency relative to untreated diabetics up to 11.3%, but the existing difference was not statistically significant. CONCLUSION: Six-week administration of VM could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-induced experimental model of diabetes mellitus and has no effect on thermal pain threshold.M RoghaniT BaluchnejadmojaradBabol University of Medical Sciencesarticlevaccinium myrtillusdiabetes mellitushyperalgesiaMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 3, Pp 22-28 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	vaccinium myrtillus diabetes mellitus hyperalgesia Medicine R Medicine (General) R5-920
spellingShingle	vaccinium myrtillus diabetes mellitus hyperalgesia Medicine R Medicine (General) R5-920 M Roghani T Baluchnejadmojarad Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats
description	BACKGROUND AND OBJECTIVE: Diabetes mellitus in long-term accompanies with inappropriate complications like retinopathy and neuropathy and increased pain sensation due to neuropathy. Since there is some evidence on protective and antidiabetic effects of Vaccinium myrtillus (VM), this study was designed to investigate the antinociceptive effect of Vaccinium myrtillus (VM) in streptozotocin-diabetic rats using formalin test and hot tail immersion tests.METHODS: In this experimental study, male rats were divided into equal-sized control, VM-treated control, diabetic, sodium salicylate (SS)-treated diabetic, and VM-treated diabetic groups. For induction of diabetes, streptozotocin at a dose of 60 mg/kg (i.p) was injected. The treatment groups received oral administration of VM-mixed pelleted food (5%) for 6 weeks with no limitation. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests.FINDINGS: VM treatment of diabetic rats reduced pain score in chronic phase up to 17.9% (p<0.05). Meanwhile, SS administration significantly reduced pain score at chronic phase of the test up to 23.6% (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant 37.4% reduction in tail flick latency as compared to control ones (p<0.05). Although VM treatment of diabetic rats increased this latency relative to untreated diabetics up to 11.3%, but the existing difference was not statistically significant. CONCLUSION: Six-week administration of VM could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-induced experimental model of diabetes mellitus and has no effect on thermal pain threshold.
format	article
author	M Roghani T Baluchnejadmojarad
author_facet	M Roghani T Baluchnejadmojarad
author_sort	M Roghani
title	Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats
title_short	Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats
title_full	Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats
title_fullStr	Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats
title_full_unstemmed	Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats
title_sort	antinociceptive effect of vaccinium myrtillus in diabetic rats
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/77c5642f31124c13b54efd7eb59e0232
work_keys_str_mv	AT mroghani antinociceptiveeffectofvacciniummyrtillusindiabeticrats AT tbaluchnejadmojarad antinociceptiveeffectofvacciniummyrtillusindiabeticrats
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Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats

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