HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.

Immune disorders may play an important role in the pathogenesis of Parkinson's disease (PD). Recently, polymorphisms in the HLA-DR region have been found to be associated with sporadic PD in European ancestry populations. However, polymorphisms in the HLA complex are highly variable with ethnic...

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Autores principales:	Congcong Sun, Lei Wei, Feifei Luo, Yi Li, Jiaobiao Li, Feiqi Zhu, Ping Kang, Rensi Xu, Lulu Xiao, Zhuolin Liu, Pingyi Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77c5a5c2922c4198a495d7a79f9b8129
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spelling	oai:doaj.org-article:77c5a5c2922c4198a495d7a79f9b81292021-11-18T08:09:55ZHLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.1932-620310.1371/journal.pone.0048594https://doaj.org/article/77c5a5c2922c4198a495d7a79f9b81292012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23139797/?tool=EBIhttps://doaj.org/toc/1932-6203Immune disorders may play an important role in the pathogenesis of Parkinson's disease (PD). Recently, polymorphisms in the HLA-DR region have been found to be associated with sporadic PD in European ancestry populations. However, polymorphisms in the HLA complex are highly variable with ethnic and geographic origin. To explore the relationships between polymorphisms of the HLA-DR region and sporadic PD in Chinese Han population, we genotyped 567 sporadic PD patients and 746 healthy controls in two independent series for the HLA-DRB1 locus with Polymerase chain reaction-sequence based typing(PCR-SBT). The χ(2) test was used to evaluate the distribution of allele frequencies between the patients and healthy controls. The impact of HLA-DRB1 alleles on PD risk was estimated by unconditional logistic regression. We found a significant higher frequency of HLA-DRB10301 in sporadic PD patients than in healthy controls and a positive association, which was independent of onset age, between HLA-DRB10301 and PD risk. Conversely, a lower frequency of HLA-DRB10406 was found in sporadic PD patients than in healthy controls, with a negative association between HLA-DRB10406 and PD risk. Furthermore, a meta-analysis involving 195205 individuals was conducted to summarize the frequencies of these two alleles in populations from various ethnic regions, we found a higher frequency of HLA-DRB10301, but a lower frequency of HLA-DRB10406 in European ancestry populations than that in Asians, this was consistent with the higher prevalence of sporadic PD in European ancestry populations. Based on these results, we speculate that HLA-DRB1 alleles are associated with the susceptibility to sporadic PD in Chinese Han population, among them HLA-DRB10301 is a risk allele while the effect of HLA-DRB10406 deserves debate.Congcong SunLei WeiFeifei LuoYi LiJiaobiao LiFeiqi ZhuPing KangRensi XuLulu XiaoZhuolin LiuPingyi XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48594 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Congcong Sun Lei Wei Feifei Luo Yi Li Jiaobiao Li Feiqi Zhu Ping Kang Rensi Xu Lulu Xiao Zhuolin Liu Pingyi Xu HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
description	Immune disorders may play an important role in the pathogenesis of Parkinson's disease (PD). Recently, polymorphisms in the HLA-DR region have been found to be associated with sporadic PD in European ancestry populations. However, polymorphisms in the HLA complex are highly variable with ethnic and geographic origin. To explore the relationships between polymorphisms of the HLA-DR region and sporadic PD in Chinese Han population, we genotyped 567 sporadic PD patients and 746 healthy controls in two independent series for the HLA-DRB1 locus with Polymerase chain reaction-sequence based typing(PCR-SBT). The χ(2) test was used to evaluate the distribution of allele frequencies between the patients and healthy controls. The impact of HLA-DRB1 alleles on PD risk was estimated by unconditional logistic regression. We found a significant higher frequency of HLA-DRB10301 in sporadic PD patients than in healthy controls and a positive association, which was independent of onset age, between HLA-DRB10301 and PD risk. Conversely, a lower frequency of HLA-DRB10406 was found in sporadic PD patients than in healthy controls, with a negative association between HLA-DRB10406 and PD risk. Furthermore, a meta-analysis involving 195205 individuals was conducted to summarize the frequencies of these two alleles in populations from various ethnic regions, we found a higher frequency of HLA-DRB10301, but a lower frequency of HLA-DRB10406 in European ancestry populations than that in Asians, this was consistent with the higher prevalence of sporadic PD in European ancestry populations. Based on these results, we speculate that HLA-DRB1 alleles are associated with the susceptibility to sporadic PD in Chinese Han population, among them HLA-DRB10301 is a risk allele while the effect of HLA-DRB10406 deserves debate.
format	article
author	Congcong Sun Lei Wei Feifei Luo Yi Li Jiaobiao Li Feiqi Zhu Ping Kang Rensi Xu Lulu Xiao Zhuolin Liu Pingyi Xu
author_facet	Congcong Sun Lei Wei Feifei Luo Yi Li Jiaobiao Li Feiqi Zhu Ping Kang Rensi Xu Lulu Xiao Zhuolin Liu Pingyi Xu
author_sort	Congcong Sun
title	HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
title_short	HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
title_full	HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
title_fullStr	HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
title_full_unstemmed	HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
title_sort	hla-drb1 alleles are associated with the susceptibility to sporadic parkinson's disease in chinese han population.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/77c5a5c2922c4198a495d7a79f9b8129
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HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.

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