Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impa...

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Autores principales:	Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77cc9364f8ea48a78af4b15a8220d6c9
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spelling	oai:doaj.org-article:77cc9364f8ea48a78af4b15a8220d6c92021-12-02T17:24:08ZCell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease10.1038/s41467-021-23909-z2041-1723https://doaj.org/article/77cc9364f8ea48a78af4b15a8220d6c92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23909-zhttps://doaj.org/toc/2041-1723Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.Michael LacyChristina BürgerAnnelie ShamiMaiwand AhmadseiHolger WinkelsKatrin NitzClaudia M. van TielTom T. P. SeijkensPascal J. H. KustersEla KarshovkaKoen H. M. PrangeYuting WuSanne L. N. BrounsSigrid UnterlugauerMarijke J. E. KuijpersMyrthe E. ReicheSabine SteffensAndreas EdsfeldtRemco T. A. MegensJohan W. M. HeemskerkIsabel GoncalvesChristian WeberNorbert GerdesDorothee AtzlerEsther LutgensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Lacy Christina Bürger Annelie Shami Maiwand Ahmadsei Holger Winkels Katrin Nitz Claudia M. van Tiel Tom T. P. Seijkens Pascal J. H. Kusters Ela Karshovka Koen H. M. Prange Yuting Wu Sanne L. N. Brouns Sigrid Unterlugauer Marijke J. E. Kuijpers Myrthe E. Reiche Sabine Steffens Andreas Edsfeldt Remco T. A. Megens Johan W. M. Heemskerk Isabel Goncalves Christian Weber Norbert Gerdes Dorothee Atzler Esther Lutgens Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
description	Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.
format	article
author	Michael Lacy Christina Bürger Annelie Shami Maiwand Ahmadsei Holger Winkels Katrin Nitz Claudia M. van Tiel Tom T. P. Seijkens Pascal J. H. Kusters Ela Karshovka Koen H. M. Prange Yuting Wu Sanne L. N. Brouns Sigrid Unterlugauer Marijke J. E. Kuijpers Myrthe E. Reiche Sabine Steffens Andreas Edsfeldt Remco T. A. Megens Johan W. M. Heemskerk Isabel Goncalves Christian Weber Norbert Gerdes Dorothee Atzler Esther Lutgens
author_facet	Michael Lacy Christina Bürger Annelie Shami Maiwand Ahmadsei Holger Winkels Katrin Nitz Claudia M. van Tiel Tom T. P. Seijkens Pascal J. H. Kusters Ela Karshovka Koen H. M. Prange Yuting Wu Sanne L. N. Brouns Sigrid Unterlugauer Marijke J. E. Kuijpers Myrthe E. Reiche Sabine Steffens Andreas Edsfeldt Remco T. A. Megens Johan W. M. Heemskerk Isabel Goncalves Christian Weber Norbert Gerdes Dorothee Atzler Esther Lutgens
author_sort	Michael Lacy
title	Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
title_short	Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
title_full	Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
title_fullStr	Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
title_full_unstemmed	Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
title_sort	cell-specific and divergent roles of the cd40l-cd40 axis in atherosclerotic vascular disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77cc9364f8ea48a78af4b15a8220d6c9
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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

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