Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impa...

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Autores principales: Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/77cc9364f8ea48a78af4b15a8220d6c9
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