Association between triglyceride glucose index and peak growth hormone in children with short stature

Abstract Growth hormone (GH) secretion is related to many factors, such as weight and puberty, and the reproducibility of GH provocation tests is very poor. This study aimed to evaluate whether the triglyceride (TyG) index was associated with peak GH in children with short stature. This study includ...

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Autores principales:	Qianqian Zhao, Yuntian Chu, Hui Pan, Mei Zhang, Bo Ban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77cc9756b5c248438f59670b2dc1e75d
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spelling	oai:doaj.org-article:77cc9756b5c248438f59670b2dc1e75d2021-12-02T13:50:41ZAssociation between triglyceride glucose index and peak growth hormone in children with short stature10.1038/s41598-021-81564-22045-2322https://doaj.org/article/77cc9756b5c248438f59670b2dc1e75d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81564-2https://doaj.org/toc/2045-2322Abstract Growth hormone (GH) secretion is related to many factors, such as weight and puberty, and the reproducibility of GH provocation tests is very poor. This study aimed to evaluate whether the triglyceride (TyG) index was associated with peak GH in children with short stature. This study included 1095 children with short stature divided into two groups based on peak GH level in GH provocation tests [GH deficiency (GHD) group = 733 children; non-GHD group = 362 children]. We found that the TyG index was significantly higher in the GHD group than in the non-GHD group (P < 0.001). A nonlinear relationship was detected between the TyG index and peak GH, whose point was 7.8. A significant negative association between the TyG index and peak GH was observed when the TyG index was greater than 7.8 (β − 2.61, 95% CI − 3.98, − 1.24; P < 0.001), whereas, the relationship between the TyG index and peak GH was not significant when the TyG index was lower than 7.8 (β 0.25, 95% CI − 1.68, 2.17; P = 0.799). There is a nonlinear relationship between the TyG index and peak GH, and a higher TyG index is associated with decreased peak GH in children with short stature.Qianqian ZhaoYuntian ChuHui PanMei ZhangBo BanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qianqian Zhao Yuntian Chu Hui Pan Mei Zhang Bo Ban Association between triglyceride glucose index and peak growth hormone in children with short stature
description	Abstract Growth hormone (GH) secretion is related to many factors, such as weight and puberty, and the reproducibility of GH provocation tests is very poor. This study aimed to evaluate whether the triglyceride (TyG) index was associated with peak GH in children with short stature. This study included 1095 children with short stature divided into two groups based on peak GH level in GH provocation tests [GH deficiency (GHD) group = 733 children; non-GHD group = 362 children]. We found that the TyG index was significantly higher in the GHD group than in the non-GHD group (P < 0.001). A nonlinear relationship was detected between the TyG index and peak GH, whose point was 7.8. A significant negative association between the TyG index and peak GH was observed when the TyG index was greater than 7.8 (β − 2.61, 95% CI − 3.98, − 1.24; P < 0.001), whereas, the relationship between the TyG index and peak GH was not significant when the TyG index was lower than 7.8 (β 0.25, 95% CI − 1.68, 2.17; P = 0.799). There is a nonlinear relationship between the TyG index and peak GH, and a higher TyG index is associated with decreased peak GH in children with short stature.
format	article
author	Qianqian Zhao Yuntian Chu Hui Pan Mei Zhang Bo Ban
author_facet	Qianqian Zhao Yuntian Chu Hui Pan Mei Zhang Bo Ban
author_sort	Qianqian Zhao
title	Association between triglyceride glucose index and peak growth hormone in children with short stature
title_short	Association between triglyceride glucose index and peak growth hormone in children with short stature
title_full	Association between triglyceride glucose index and peak growth hormone in children with short stature
title_fullStr	Association between triglyceride glucose index and peak growth hormone in children with short stature
title_full_unstemmed	Association between triglyceride glucose index and peak growth hormone in children with short stature
title_sort	association between triglyceride glucose index and peak growth hormone in children with short stature
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77cc9756b5c248438f59670b2dc1e75d
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Association between triglyceride glucose index and peak growth hormone in children with short stature

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