A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors

Abstract Neural progenitor cells undergo identity transitions during development to ensure the generation different types of neurons and glia in the correct sequence and proportions. A number of temporal identity factors that control these transitions in progenitor competence have been identified, b...

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Autores principales:	Pierre Mattar, Christine Jolicoeur, Thanh Dang, Sujay Shah, Brian S. Clark, Michel Cayouette
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77cfb57cb22b40868d46df39a2318f29
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spelling	oai:doaj.org-article:77cfb57cb22b40868d46df39a2318f292021-12-02T12:11:12ZA Casz1–NuRD complex regulates temporal identity transitions in neural progenitors10.1038/s41598-021-83395-72045-2322https://doaj.org/article/77cfb57cb22b40868d46df39a2318f292021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83395-7https://doaj.org/toc/2045-2322Abstract Neural progenitor cells undergo identity transitions during development to ensure the generation different types of neurons and glia in the correct sequence and proportions. A number of temporal identity factors that control these transitions in progenitor competence have been identified, but the molecular mechanisms underlying their function remain unclear. Here, we asked how Casz1, the mammalian orthologue of Drosophila castor, regulates competence during retinal development. We show that Casz1 is required to control the transition between neurogenesis and gliogenesis. Using BioID proteomics, we reveal that Casz1 interacts with the nucleosome remodeling and deacetylase (NuRD) complex in retinal cells. Finally, we show that both the NuRD and the polycomb repressor complexes are required for Casz1 to promote the rod fate and suppress gliogenesis. As additional temporal identity factors have been found to interact with the NuRD complex in other contexts, we propose that these factors might act through this common biochemical process to regulate neurogenesis.Pierre MattarChristine JolicoeurThanh DangSujay ShahBrian S. ClarkMichel CayouetteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pierre Mattar Christine Jolicoeur Thanh Dang Sujay Shah Brian S. Clark Michel Cayouette A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors
description	Abstract Neural progenitor cells undergo identity transitions during development to ensure the generation different types of neurons and glia in the correct sequence and proportions. A number of temporal identity factors that control these transitions in progenitor competence have been identified, but the molecular mechanisms underlying their function remain unclear. Here, we asked how Casz1, the mammalian orthologue of Drosophila castor, regulates competence during retinal development. We show that Casz1 is required to control the transition between neurogenesis and gliogenesis. Using BioID proteomics, we reveal that Casz1 interacts with the nucleosome remodeling and deacetylase (NuRD) complex in retinal cells. Finally, we show that both the NuRD and the polycomb repressor complexes are required for Casz1 to promote the rod fate and suppress gliogenesis. As additional temporal identity factors have been found to interact with the NuRD complex in other contexts, we propose that these factors might act through this common biochemical process to regulate neurogenesis.
format	article
author	Pierre Mattar Christine Jolicoeur Thanh Dang Sujay Shah Brian S. Clark Michel Cayouette
author_facet	Pierre Mattar Christine Jolicoeur Thanh Dang Sujay Shah Brian S. Clark Michel Cayouette
author_sort	Pierre Mattar
title	A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors
title_short	A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors
title_full	A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors
title_fullStr	A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors
title_full_unstemmed	A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors
title_sort	casz1–nurd complex regulates temporal identity transitions in neural progenitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77cfb57cb22b40868d46df39a2318f29
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A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors

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