Elevated levels of Wnt signaling disrupt thymus morphogenesis and function

Abstract All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered. Here, we demonstrate that, in contrast to...

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Bibliographic Details
Main Authors: Jeremy B. Swann, Christiane Happe, Thomas Boehm
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/77d9ffad1f2241eab4bd1f1a5200e4ce
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