Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.

<h4>Background</h4>Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart dis...

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Autores principales:	Peter Willeit, Alexander Thompson, Thor Aspelund, Ann Rumley, Gudny Eiriksdottir, Gordon Lowe, Vilmundur Gudnason, Emanuele Di Angelantonio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77db2959f564416e85ae5c7b5b8aa9c8
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spelling	oai:doaj.org-article:77db2959f564416e85ae5c7b5b8aa9c82021-11-18T07:58:23ZHemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.1932-620310.1371/journal.pone.0055175https://doaj.org/article/77db2959f564416e85ae5c7b5b8aa9c82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23408959/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk.<h4>Design</h4>Prospective case-control study, systematic review and meta-analyses.<h4>Methods</h4>Measurements were made in 1925 people who had a first-ever nonfatal myocardial infarction or died of coronary heart disease during follow-up (median 19.4 years) and in 3616 controls nested within the prospective population-based Reykjavik Study.<h4>Results</h4>Age and sex-adjusted odds ratios for coronary heart disease per 1 standard deviation higher baseline level were 1.25 (1.18, 1.33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF. After additional adjustment for conventional cardiovascular risk factors, corresponding odds ratios were 1.07 (0.99, 1.14) for t-PA antigen, 1.06 (1.00, 1.13) for D-dimer and 1.08 (1.02, 1.15) for VWF. When combined with the results from previous prospective studies in a random-effects meta-analysis, overall adjusted odds ratios were 1.13 (1.06, 1.21) for t-PA antigen (13 studies, 5494 cases), 1.23 (1.16, 1.32) with D-dimer (18 studies, 6799 cases) and 1.16 (1.10, 1.22) with VWF (15 studies, 6556 cases).<h4>Conclusions</h4>Concentrations of t-PA antigen, D-dimer and VWF may be more modestly associated with first-ever CHD events than previously reported. More detailed analysis is required to clarify whether these markers are causal risk factors or simply correlates of coronary heart disease.Peter WilleitAlexander ThompsonThor AspelundAnn RumleyGudny EiriksdottirGordon LoweVilmundur GudnasonEmanuele Di AngelantonioPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55175 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Willeit Alexander Thompson Thor Aspelund Ann Rumley Gudny Eiriksdottir Gordon Lowe Vilmundur Gudnason Emanuele Di Angelantonio Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
description	<h4>Background</h4>Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk.<h4>Design</h4>Prospective case-control study, systematic review and meta-analyses.<h4>Methods</h4>Measurements were made in 1925 people who had a first-ever nonfatal myocardial infarction or died of coronary heart disease during follow-up (median 19.4 years) and in 3616 controls nested within the prospective population-based Reykjavik Study.<h4>Results</h4>Age and sex-adjusted odds ratios for coronary heart disease per 1 standard deviation higher baseline level were 1.25 (1.18, 1.33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF. After additional adjustment for conventional cardiovascular risk factors, corresponding odds ratios were 1.07 (0.99, 1.14) for t-PA antigen, 1.06 (1.00, 1.13) for D-dimer and 1.08 (1.02, 1.15) for VWF. When combined with the results from previous prospective studies in a random-effects meta-analysis, overall adjusted odds ratios were 1.13 (1.06, 1.21) for t-PA antigen (13 studies, 5494 cases), 1.23 (1.16, 1.32) with D-dimer (18 studies, 6799 cases) and 1.16 (1.10, 1.22) with VWF (15 studies, 6556 cases).<h4>Conclusions</h4>Concentrations of t-PA antigen, D-dimer and VWF may be more modestly associated with first-ever CHD events than previously reported. More detailed analysis is required to clarify whether these markers are causal risk factors or simply correlates of coronary heart disease.
format	article
author	Peter Willeit Alexander Thompson Thor Aspelund Ann Rumley Gudny Eiriksdottir Gordon Lowe Vilmundur Gudnason Emanuele Di Angelantonio
author_facet	Peter Willeit Alexander Thompson Thor Aspelund Ann Rumley Gudny Eiriksdottir Gordon Lowe Vilmundur Gudnason Emanuele Di Angelantonio
author_sort	Peter Willeit
title	Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
title_short	Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
title_full	Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
title_fullStr	Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
title_full_unstemmed	Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
title_sort	hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/77db2959f564416e85ae5c7b5b8aa9c8
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Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.

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