Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo.

Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo.

<h4>Background</h4>Drug resistance, a process mediated by multiple mechanisms, is a critical determinant for treating lung cancer. The aim of this study is to determine if oleanolic acid (OA), a pentacyclic triterpene present in several plants, is able to circumvent the mechanisms of dru...

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Autores principales: Kelly Araújo Lúcio, Gleice da Graça Rocha, Leonardo Campos Monção-Ribeiro, Janaina Fernandes, Christina Maeda Takiya, Cerli Rocha Gattass
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/77dbe79e22eb47009878f813b5309a88
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