Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from...

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Autores principales:	Kristyna Sloupenska, Jana Dolezilkova, Barbora Koubkova, Beata Hutyrova, Mojmir Racansky, Pavel Horak, Maryna Golovchenko, Milan Raska, Natalie Rudenko, Michal Krupka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ticks co-infection Lyme disease post-treatment Lyme disease syndrome <i>Bartonella</i> <i>Anaplasma</i> Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/77df69ff5bd94f89aa1d1ff381a68c74
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spelling	oai:doaj.org-article:77df69ff5bd94f89aa1d1ff381a68c742021-11-25T18:24:19ZSeroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome10.3390/microorganisms91122172076-2607https://doaj.org/article/77df69ff5bd94f89aa1d1ff381a68c742021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2217https://doaj.org/toc/2076-2607The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from 103 patients with suspected post-treatment Lyme disease syndrome were tested for the presence of antibodies to the major tick-borne pathogens <i>Anaplasma phagocytophilum</i>, <i>Bartonella henselae</i>/<i>Bartonella quinatana</i>, and <i>Babesia microti</i>. Although the presence of anti-<i>Anaplasma</i> antibodies was detected in 12.6% of the samples and anti-<i>Bartonella</i> antibodies in 9.7% of the samples, the presence of antibodies against both pathogens in the same samples or anti-<i>Babesia</i> antibodies in the selected group of patients could not be confirmed. However, we were able to detect autoantibodies, mostly antinuclear, in 11.6% of the patients studied. Our results are in good agreement with previously published studies showing the presence of a wide spectrum of autoantibodies in some patients with complicated forms of Lyme disease and post-treatment Lyme disease syndrome, but they do not reveal a significant influence of co-infections on the development of PTLDS in the studied group of patients.Kristyna SloupenskaJana DolezilkovaBarbora KoubkovaBeata HutyrovaMojmir RacanskyPavel HorakMaryna GolovchenkoMilan RaskaNatalie RudenkoMichal KrupkaMDPI AGarticleticksco-infectionLyme diseasepost-treatment Lyme disease syndrome<i>Bartonella</i><i>Anaplasma</i>Biology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2217, p 2217 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ticks co-infection Lyme disease post-treatment Lyme disease syndrome <i>Bartonella</i> <i>Anaplasma</i> Biology (General) QH301-705.5
spellingShingle	ticks co-infection Lyme disease post-treatment Lyme disease syndrome <i>Bartonella</i> <i>Anaplasma</i> Biology (General) QH301-705.5 Kristyna Sloupenska Jana Dolezilkova Barbora Koubkova Beata Hutyrova Mojmir Racansky Pavel Horak Maryna Golovchenko Milan Raska Natalie Rudenko Michal Krupka Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome
description	The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from 103 patients with suspected post-treatment Lyme disease syndrome were tested for the presence of antibodies to the major tick-borne pathogens <i>Anaplasma phagocytophilum</i>, <i>Bartonella henselae</i>/<i>Bartonella quinatana</i>, and <i>Babesia microti</i>. Although the presence of anti-<i>Anaplasma</i> antibodies was detected in 12.6% of the samples and anti-<i>Bartonella</i> antibodies in 9.7% of the samples, the presence of antibodies against both pathogens in the same samples or anti-<i>Babesia</i> antibodies in the selected group of patients could not be confirmed. However, we were able to detect autoantibodies, mostly antinuclear, in 11.6% of the patients studied. Our results are in good agreement with previously published studies showing the presence of a wide spectrum of autoantibodies in some patients with complicated forms of Lyme disease and post-treatment Lyme disease syndrome, but they do not reveal a significant influence of co-infections on the development of PTLDS in the studied group of patients.
format	article
author	Kristyna Sloupenska Jana Dolezilkova Barbora Koubkova Beata Hutyrova Mojmir Racansky Pavel Horak Maryna Golovchenko Milan Raska Natalie Rudenko Michal Krupka
author_facet	Kristyna Sloupenska Jana Dolezilkova Barbora Koubkova Beata Hutyrova Mojmir Racansky Pavel Horak Maryna Golovchenko Milan Raska Natalie Rudenko Michal Krupka
author_sort	Kristyna Sloupenska
title	Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_short	Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_full	Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_fullStr	Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_full_unstemmed	Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_sort	seroprevalence of antibodies against tick-borne pathogens in czech patients with suspected post-treatment lyme disease syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/77df69ff5bd94f89aa1d1ff381a68c74
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Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

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