Nanoparticles for Ferroptosis Therapy in Cancer

Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability...

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Autores principales:	Nadia Zaffaroni, Giovanni Luca Beretta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ferroptosis nanoparticles cancer tumor targeting iron Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/77e10f2cd58842fdaa46bd22e0040462
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spelling	oai:doaj.org-article:77e10f2cd58842fdaa46bd22e00404622021-11-25T18:40:40ZNanoparticles for Ferroptosis Therapy in Cancer10.3390/pharmaceutics131117851999-4923https://doaj.org/article/77e10f2cd58842fdaa46bd22e00404622021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1785https://doaj.org/toc/1999-4923Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy.Nadia ZaffaroniGiovanni Luca BerettaMDPI AGarticleferroptosisnanoparticlescancertumor targetingironPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1785, p 1785 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis nanoparticles cancer tumor targeting iron Pharmacy and materia medica RS1-441
spellingShingle	ferroptosis nanoparticles cancer tumor targeting iron Pharmacy and materia medica RS1-441 Nadia Zaffaroni Giovanni Luca Beretta Nanoparticles for Ferroptosis Therapy in Cancer
description	Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy.
format	article
author	Nadia Zaffaroni Giovanni Luca Beretta
author_facet	Nadia Zaffaroni Giovanni Luca Beretta
author_sort	Nadia Zaffaroni
title	Nanoparticles for Ferroptosis Therapy in Cancer
title_short	Nanoparticles for Ferroptosis Therapy in Cancer
title_full	Nanoparticles for Ferroptosis Therapy in Cancer
title_fullStr	Nanoparticles for Ferroptosis Therapy in Cancer
title_full_unstemmed	Nanoparticles for Ferroptosis Therapy in Cancer
title_sort	nanoparticles for ferroptosis therapy in cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/77e10f2cd58842fdaa46bd22e0040462
work_keys_str_mv	AT nadiazaffaroni nanoparticlesforferroptosistherapyincancer AT giovannilucaberetta nanoparticlesforferroptosistherapyincancer
_version_	1718410842950598656

Nanoparticles for Ferroptosis Therapy in Cancer

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