Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research

ABSTRACT The “reproducibility crisis” in science affects microbiology as much as any other area of inquiry, and microbiologists have long struggled to make their research reproducible. We need to respect that ensuring that our methods and results are sufficiently transparent is difficult. This diffi...

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Autor principal:	Patrick D. Schloss
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	American Academy of Microbiology microbiome reproducibility research ethics scientific method Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/77e200f6280a480da11ba9ef90f20b7a
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spelling	oai:doaj.org-article:77e200f6280a480da11ba9ef90f20b7a2021-11-15T16:00:27ZIdentifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research10.1128/mBio.00525-182150-7511https://doaj.org/article/77e200f6280a480da11ba9ef90f20b7a2018-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00525-18https://doaj.org/toc/2150-7511ABSTRACT The “reproducibility crisis” in science affects microbiology as much as any other area of inquiry, and microbiologists have long struggled to make their research reproducible. We need to respect that ensuring that our methods and results are sufficiently transparent is difficult. This difficulty is compounded in interdisciplinary fields such as microbiome research. There are many reasons why a researcher is unable to reproduce a previous result, and even if a result is reproducible, it may not be correct. Furthermore, failures to reproduce previous results have much to teach us about the scientific process and microbial life itself. This Perspective delineates a framework for identifying and overcoming threats to reproducibility, replicability, robustness, and generalizability of microbiome research. Instead of seeing signs of a crisis in others’ work, we need to appreciate the technical and social difficulties that limit reproducibility in the work of others as well as our own.Patrick D. SchlossAmerican Society for MicrobiologyarticleAmerican Academy of Microbiologymicrobiomereproducibilityresearch ethicsscientific methodMicrobiologyQR1-502ENmBio, Vol 9, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	American Academy of Microbiology microbiome reproducibility research ethics scientific method Microbiology QR1-502
spellingShingle	American Academy of Microbiology microbiome reproducibility research ethics scientific method Microbiology QR1-502 Patrick D. Schloss Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research
description	ABSTRACT The “reproducibility crisis” in science affects microbiology as much as any other area of inquiry, and microbiologists have long struggled to make their research reproducible. We need to respect that ensuring that our methods and results are sufficiently transparent is difficult. This difficulty is compounded in interdisciplinary fields such as microbiome research. There are many reasons why a researcher is unable to reproduce a previous result, and even if a result is reproducible, it may not be correct. Furthermore, failures to reproduce previous results have much to teach us about the scientific process and microbial life itself. This Perspective delineates a framework for identifying and overcoming threats to reproducibility, replicability, robustness, and generalizability of microbiome research. Instead of seeing signs of a crisis in others’ work, we need to appreciate the technical and social difficulties that limit reproducibility in the work of others as well as our own.
format	article
author	Patrick D. Schloss
author_facet	Patrick D. Schloss
author_sort	Patrick D. Schloss
title	Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research
title_short	Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research
title_full	Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research
title_fullStr	Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research
title_full_unstemmed	Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research
title_sort	identifying and overcoming threats to reproducibility, replicability, robustness, and generalizability in microbiome research
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/77e200f6280a480da11ba9ef90f20b7a
work_keys_str_mv	AT patrickdschloss identifyingandovercomingthreatstoreproducibilityreplicabilityrobustnessandgeneralizabilityinmicrobiomeresearch
_version_	1718426975096274944

Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research

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