Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.

HIV-1 cell-to-cell transmission allows for 2-3 orders of magnitude more efficient viral spread than cell-free dissemination. The high local multiplicity of infection (MOI) observed at cell-cell contact sites may lower the efficacy of antiretroviral therapies (ART). Here we test the efficacy of commo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luis M Agosto, Peng Zhong, James Munro, Walther Mothes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/77e62d58c4a947549b61ec6e58e2b001
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77e62d58c4a947549b61ec6e58e2b001
record_format	dspace
spelling	oai:doaj.org-article:77e62d58c4a947549b61ec6e58e2b0012021-11-18T06:06:54ZHighly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.1553-73661553-737410.1371/journal.ppat.1003982https://doaj.org/article/77e62d58c4a947549b61ec6e58e2b0012014-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586176/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374HIV-1 cell-to-cell transmission allows for 2-3 orders of magnitude more efficient viral spread than cell-free dissemination. The high local multiplicity of infection (MOI) observed at cell-cell contact sites may lower the efficacy of antiretroviral therapies (ART). Here we test the efficacy of commonly used antiretroviral inhibitors against cell-to-cell and cell-free HIV-1 transmission. We demonstrate that, while some nucleoside-analog reverse transcriptase inhibitors (NRTI) are less effective against HIV-1 cell-to-cell transmission, most non-nucleoside-analog reverse transcriptase inhibitors (NNRTI), entry inhibitors and protease inhibitors remain highly effective. Moreover, poor NRTIs become highly effective when applied in combinations explaining the effectiveness of ART in clinical settings. Investigating the underlying mechanism, we observe a strict correlation between the ability of individual drugs and combinations of drugs to interfere with HIV-1 cell-to-cell transmission, and their effectiveness against high viral MOIs. Our results suggest that the ability to suppress high viral MOI is a feature of effective ART regimens and this parameter should be considered when designing novel antiviral therapies.Luis M AgostoPeng ZhongJames MunroWalther MothesPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 2, p e1003982 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Luis M Agosto Peng Zhong James Munro Walther Mothes Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
description	HIV-1 cell-to-cell transmission allows for 2-3 orders of magnitude more efficient viral spread than cell-free dissemination. The high local multiplicity of infection (MOI) observed at cell-cell contact sites may lower the efficacy of antiretroviral therapies (ART). Here we test the efficacy of commonly used antiretroviral inhibitors against cell-to-cell and cell-free HIV-1 transmission. We demonstrate that, while some nucleoside-analog reverse transcriptase inhibitors (NRTI) are less effective against HIV-1 cell-to-cell transmission, most non-nucleoside-analog reverse transcriptase inhibitors (NNRTI), entry inhibitors and protease inhibitors remain highly effective. Moreover, poor NRTIs become highly effective when applied in combinations explaining the effectiveness of ART in clinical settings. Investigating the underlying mechanism, we observe a strict correlation between the ability of individual drugs and combinations of drugs to interfere with HIV-1 cell-to-cell transmission, and their effectiveness against high viral MOIs. Our results suggest that the ability to suppress high viral MOI is a feature of effective ART regimens and this parameter should be considered when designing novel antiviral therapies.
format	article
author	Luis M Agosto Peng Zhong James Munro Walther Mothes
author_facet	Luis M Agosto Peng Zhong James Munro Walther Mothes
author_sort	Luis M Agosto
title	Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
title_short	Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
title_full	Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
title_fullStr	Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
title_full_unstemmed	Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
title_sort	highly active antiretroviral therapies are effective against hiv-1 cell-to-cell transmission.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/77e62d58c4a947549b61ec6e58e2b001
work_keys_str_mv	AT luismagosto highlyactiveantiretroviraltherapiesareeffectiveagainsthiv1celltocelltransmission AT pengzhong highlyactiveantiretroviraltherapiesareeffectiveagainsthiv1celltocelltransmission AT jamesmunro highlyactiveantiretroviraltherapiesareeffectiveagainsthiv1celltocelltransmission AT walthermothes highlyactiveantiretroviraltherapiesareeffectiveagainsthiv1celltocelltransmission
_version_	1718424545927364608

Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.

Ejemplares similares