Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex

Abstract Transcutaneous spinal direct current stimulation (tsDCS) is a safe and convenient method of neuromodulation. It has been proven to alter sensory processing at cervicomedullary level by amplitude changes of the P30 response of tibial nerve somatosensory evoked potentials (TN SEPs). With know...

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Autores principales:	Jan H. Bettmann, Christine H. Meyer-Frießem, Lauren M. Schweizer, Lara Schlaffke, Peter K. Zahn, Martin Tegenthoff, Oliver Höffken
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77e701a301784ed9a1e87053aad45a12
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spelling	oai:doaj.org-article:77e701a301784ed9a1e87053aad45a122021-12-02T12:42:18ZTranscutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex10.1038/s41598-020-79131-22045-2322https://doaj.org/article/77e701a301784ed9a1e87053aad45a122020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79131-2https://doaj.org/toc/2045-2322Abstract Transcutaneous spinal direct current stimulation (tsDCS) is a safe and convenient method of neuromodulation. It has been proven to alter sensory processing at cervicomedullary level by amplitude changes of the P30 response of tibial nerve somatosensory evoked potentials (TN SEPs). With knowledge that tsDCS affects cortical circuits, we hypothesized that tsDCS may also affect intracortical excitability of the somatosensory cortex assessed by paired stimulation suppression (PSS). Fourteen healthy men were included in this prospective, single-blinded, placebo-controlled crossover study. Single (SS) and paired stimulation (PS) TN SEPs were recorded over the scalp before, immediately as well as 30 and 60 min after applying 15 min of tsDCS over the twelfth thoracic vertebra. Each volunteer underwent three independent and randomized sessions of either cathodal, anodal or sham stimulation. tsDCS showed no effect on peak-to-peak amplitudes or latencies of cortical P40-N50 response after SS. Furthermore, tsDCS failed to induce significant changes on amplitude ratios of PSS, thus showing no impact on intracortical excitability of the somatosensory cortex in healthy subjects. Further research is required to reveal the different mechanisms and to strengthen clinical use of this promising technique.Jan H. BettmannChristine H. Meyer-FrießemLauren M. SchweizerLara SchlaffkePeter K. ZahnMartin TegenthoffOliver HöffkenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan H. Bettmann Christine H. Meyer-Frießem Lauren M. Schweizer Lara Schlaffke Peter K. Zahn Martin Tegenthoff Oliver Höffken Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
description	Abstract Transcutaneous spinal direct current stimulation (tsDCS) is a safe and convenient method of neuromodulation. It has been proven to alter sensory processing at cervicomedullary level by amplitude changes of the P30 response of tibial nerve somatosensory evoked potentials (TN SEPs). With knowledge that tsDCS affects cortical circuits, we hypothesized that tsDCS may also affect intracortical excitability of the somatosensory cortex assessed by paired stimulation suppression (PSS). Fourteen healthy men were included in this prospective, single-blinded, placebo-controlled crossover study. Single (SS) and paired stimulation (PS) TN SEPs were recorded over the scalp before, immediately as well as 30 and 60 min after applying 15 min of tsDCS over the twelfth thoracic vertebra. Each volunteer underwent three independent and randomized sessions of either cathodal, anodal or sham stimulation. tsDCS showed no effect on peak-to-peak amplitudes or latencies of cortical P40-N50 response after SS. Furthermore, tsDCS failed to induce significant changes on amplitude ratios of PSS, thus showing no impact on intracortical excitability of the somatosensory cortex in healthy subjects. Further research is required to reveal the different mechanisms and to strengthen clinical use of this promising technique.
format	article
author	Jan H. Bettmann Christine H. Meyer-Frießem Lauren M. Schweizer Lara Schlaffke Peter K. Zahn Martin Tegenthoff Oliver Höffken
author_facet	Jan H. Bettmann Christine H. Meyer-Frießem Lauren M. Schweizer Lara Schlaffke Peter K. Zahn Martin Tegenthoff Oliver Höffken
author_sort	Jan H. Bettmann
title	Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
title_short	Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
title_full	Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
title_fullStr	Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
title_full_unstemmed	Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
title_sort	transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/77e701a301784ed9a1e87053aad45a12
work_keys_str_mv	AT janhbettmann transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex AT christinehmeyerfrießem transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex AT laurenmschweizer transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex AT laraschlaffke transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex AT peterkzahn transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex AT martintegenthoff transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex AT oliverhoffken transcutaneousspinaldirectcurrentstimulationshowsnoeffectonpairedstimulationsuppressionofthesomatosensorycortex
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Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex

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