Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

Varicella-zoster virus (VZV) establishes lifelong neuronal latency in humans. Here, Ouwendijk and Depledge et al. identify a fusion transcript, VLT-ORF63, which is expressed during lytic and latent infection, and demonstrate a role for the translated fusion protein in induction of lytic gene express...

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Autores principales:	Werner J. D. Ouwendijk, Daniel P. Depledge, Labchan Rajbhandari, Tihana Lenac Rovis, Stipan Jonjic, Judith Breuer, Arun Venkatesan, Georges M. G. M. Verjans, Tomohiko Sadaoka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77e9fbb4bab3420d9944cbe543a9206c
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spelling	oai:doaj.org-article:77e9fbb4bab3420d9944cbe543a9206c2021-12-02T10:48:19ZVaricella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency10.1038/s41467-020-20031-42041-1723https://doaj.org/article/77e9fbb4bab3420d9944cbe543a9206c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20031-4https://doaj.org/toc/2041-1723Varicella-zoster virus (VZV) establishes lifelong neuronal latency in humans. Here, Ouwendijk and Depledge et al. identify a fusion transcript, VLT-ORF63, which is expressed during lytic and latent infection, and demonstrate a role for the translated fusion protein in induction of lytic gene expression from latent VZV genomes.Werner J. D. OuwendijkDaniel P. DepledgeLabchan RajbhandariTihana Lenac RovisStipan JonjicJudith BreuerArun VenkatesanGeorges M. G. M. VerjansTomohiko SadaokaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Werner J. D. Ouwendijk Daniel P. Depledge Labchan Rajbhandari Tihana Lenac Rovis Stipan Jonjic Judith Breuer Arun Venkatesan Georges M. G. M. Verjans Tomohiko Sadaoka Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
description	Varicella-zoster virus (VZV) establishes lifelong neuronal latency in humans. Here, Ouwendijk and Depledge et al. identify a fusion transcript, VLT-ORF63, which is expressed during lytic and latent infection, and demonstrate a role for the translated fusion protein in induction of lytic gene expression from latent VZV genomes.
format	article
author	Werner J. D. Ouwendijk Daniel P. Depledge Labchan Rajbhandari Tihana Lenac Rovis Stipan Jonjic Judith Breuer Arun Venkatesan Georges M. G. M. Verjans Tomohiko Sadaoka
author_facet	Werner J. D. Ouwendijk Daniel P. Depledge Labchan Rajbhandari Tihana Lenac Rovis Stipan Jonjic Judith Breuer Arun Venkatesan Georges M. G. M. Verjans Tomohiko Sadaoka
author_sort	Werner J. D. Ouwendijk
title	Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
title_short	Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
title_full	Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
title_fullStr	Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
title_full_unstemmed	Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
title_sort	varicella-zoster virus vlt-orf63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/77e9fbb4bab3420d9944cbe543a9206c
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Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

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