Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis

Long-term infection of cystic fibrosis patients with Pseudomonas aeruginosa is often accompanied by a reduction in bacterial growth rate. Here, La Rosa et al. use adaptive laboratory evolution to increase the growth rate of clinical isolates, and identify mechanisms and evolutionary trajectories tha...

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Autores principales:	Ruggero La Rosa, Elio Rossi, Adam M. Feist, Helle Krogh Johansen, Søren Molin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77edf098233f44a1966cd50720f3827d
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spelling	oai:doaj.org-article:77edf098233f44a1966cd50720f3827d2021-12-02T16:53:16ZCompensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis10.1038/s41467-021-23451-y2041-1723https://doaj.org/article/77edf098233f44a1966cd50720f3827d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23451-yhttps://doaj.org/toc/2041-1723Long-term infection of cystic fibrosis patients with Pseudomonas aeruginosa is often accompanied by a reduction in bacterial growth rate. Here, La Rosa et al. use adaptive laboratory evolution to increase the growth rate of clinical isolates, and identify mechanisms and evolutionary trajectories that, in reverse direction, may help the pathogen to adapt to the patients’ airways.Ruggero La RosaElio RossiAdam M. FeistHelle Krogh JohansenSøren MolinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruggero La Rosa Elio Rossi Adam M. Feist Helle Krogh Johansen Søren Molin Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
description	Long-term infection of cystic fibrosis patients with Pseudomonas aeruginosa is often accompanied by a reduction in bacterial growth rate. Here, La Rosa et al. use adaptive laboratory evolution to increase the growth rate of clinical isolates, and identify mechanisms and evolutionary trajectories that, in reverse direction, may help the pathogen to adapt to the patients’ airways.
format	article
author	Ruggero La Rosa Elio Rossi Adam M. Feist Helle Krogh Johansen Søren Molin
author_facet	Ruggero La Rosa Elio Rossi Adam M. Feist Helle Krogh Johansen Søren Molin
author_sort	Ruggero La Rosa
title	Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
title_short	Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
title_full	Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
title_fullStr	Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
title_full_unstemmed	Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
title_sort	compensatory evolution of pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77edf098233f44a1966cd50720f3827d
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Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis

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