Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens

ABSTRACT: Laying hens experience a rapid decline in egg production, egg quality, and immunity, usually at the end of the peak laying period. Quercetin, a known flavonoid, exerts biological activities, including phytoestrogenic, immunity, antibiotic, antioxidant, and anti-inflammatory properties. Vit...

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Autores principales:	Felix Kwame Amevor, Zhifu Cui, Zifan Ning, Xiaxia Du, Ningning Jin, Gang Shu, Xun Deng, Qing Zhu, Yaofu Tian, Diyan Li, Yan Wang, Zhichao Zhang, Xiaoling Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	quercetin vitamin E aging breeder hen egg production immunity Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/77f1ba14c6b24a0b814183ec4ea4604b
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spelling	oai:doaj.org-article:77f1ba14c6b24a0b814183ec4ea4604b2021-11-24T04:22:08ZSynergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens0032-579110.1016/j.psj.2021.101481https://doaj.org/article/77f1ba14c6b24a0b814183ec4ea4604b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0032579121005034https://doaj.org/toc/0032-5791ABSTRACT: Laying hens experience a rapid decline in egg production, egg quality, and immunity, usually at the end of the peak laying period. Quercetin, a known flavonoid, exerts biological activities, including phytoestrogenic, immunity, antibiotic, antioxidant, and anti-inflammatory properties. Vitamin E also shows egg production and immunoregulatory potential in animals. This study evaluated the capacity of dietary quercetin, vitamin E, and the combination of both, to promote egg production and egg quality, and to improve the immunity of aging breeder hens. We also elucidated how quercetin and vitamin E combination could synergistically affect egg production, egg quality, and immunity in aging breeder hens. A total of 400 Tianfu broiler breeders at the age of 52 wk were randomly allotted to 4 treatments with 4 replicates, 100 hens per treatment and 25 hens per replicate. They were fed diets containing quercetin at 0.4 g/kg, Vitamin E (200 mg/kg), quercetin and vitamin E (0.4 g/kg and 200 mg/kg), and a basal diet (control) for a period 10 wk. Daily feed intake and egg production rate were recorded, and weekly records were recorded on egg quality tests. At the end of the 10-wk experimental period, blood samples and immune organ (spleen) were collected from 2 birds per replicate, totaling 32 birds. Feed intake, immune organ index, serum cytokines, and immunoglobulins were evaluated, and the mRNA expression of genes related to immunity was determined from the spleen tissue. Generally, the results showed that separately or as a combination, supplemental quercetin and vitamin E significantly improved performance and egg quality (P < 0.05), and significantly increased serum immunoglobulins (IgA, IgM, and IgG) and cytokines (IFN-γ and IL-2) concentrations, as well as promoted immune organ development and index, and promoted the expression of splenic immune-related genes (IL-2 and INF-γ) (P < 0.05), compared with the control. It was confirmed in this study that the combination of quercetin and vitamin E exert synergistic effects on egg production, egg quality, and immune function in aging hens.Felix Kwame AmevorZhifu CuiZifan NingXiaxia DuNingning JinGang ShuXun DengQing ZhuYaofu TianDiyan LiYan WangZhichao ZhangXiaoling ZhaoElsevierarticlequercetinvitamin Eaging breeder henegg productionimmunityAnimal cultureSF1-1100ENPoultry Science, Vol 100, Iss 12, Pp 101481- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	quercetin vitamin E aging breeder hen egg production immunity Animal culture SF1-1100
spellingShingle	quercetin vitamin E aging breeder hen egg production immunity Animal culture SF1-1100 Felix Kwame Amevor Zhifu Cui Zifan Ning Xiaxia Du Ningning Jin Gang Shu Xun Deng Qing Zhu Yaofu Tian Diyan Li Yan Wang Zhichao Zhang Xiaoling Zhao Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens
description	ABSTRACT: Laying hens experience a rapid decline in egg production, egg quality, and immunity, usually at the end of the peak laying period. Quercetin, a known flavonoid, exerts biological activities, including phytoestrogenic, immunity, antibiotic, antioxidant, and anti-inflammatory properties. Vitamin E also shows egg production and immunoregulatory potential in animals. This study evaluated the capacity of dietary quercetin, vitamin E, and the combination of both, to promote egg production and egg quality, and to improve the immunity of aging breeder hens. We also elucidated how quercetin and vitamin E combination could synergistically affect egg production, egg quality, and immunity in aging breeder hens. A total of 400 Tianfu broiler breeders at the age of 52 wk were randomly allotted to 4 treatments with 4 replicates, 100 hens per treatment and 25 hens per replicate. They were fed diets containing quercetin at 0.4 g/kg, Vitamin E (200 mg/kg), quercetin and vitamin E (0.4 g/kg and 200 mg/kg), and a basal diet (control) for a period 10 wk. Daily feed intake and egg production rate were recorded, and weekly records were recorded on egg quality tests. At the end of the 10-wk experimental period, blood samples and immune organ (spleen) were collected from 2 birds per replicate, totaling 32 birds. Feed intake, immune organ index, serum cytokines, and immunoglobulins were evaluated, and the mRNA expression of genes related to immunity was determined from the spleen tissue. Generally, the results showed that separately or as a combination, supplemental quercetin and vitamin E significantly improved performance and egg quality (P < 0.05), and significantly increased serum immunoglobulins (IgA, IgM, and IgG) and cytokines (IFN-γ and IL-2) concentrations, as well as promoted immune organ development and index, and promoted the expression of splenic immune-related genes (IL-2 and INF-γ) (P < 0.05), compared with the control. It was confirmed in this study that the combination of quercetin and vitamin E exert synergistic effects on egg production, egg quality, and immune function in aging hens.
format	article
author	Felix Kwame Amevor Zhifu Cui Zifan Ning Xiaxia Du Ningning Jin Gang Shu Xun Deng Qing Zhu Yaofu Tian Diyan Li Yan Wang Zhichao Zhang Xiaoling Zhao
author_facet	Felix Kwame Amevor Zhifu Cui Zifan Ning Xiaxia Du Ningning Jin Gang Shu Xun Deng Qing Zhu Yaofu Tian Diyan Li Yan Wang Zhichao Zhang Xiaoling Zhao
author_sort	Felix Kwame Amevor
title	Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens
title_short	Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens
title_full	Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens
title_fullStr	Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens
title_full_unstemmed	Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens
title_sort	synergistic effects of quercetin and vitamin e on egg production, egg quality, and immunity in aging breeder hens
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/77f1ba14c6b24a0b814183ec4ea4604b
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Synergistic effects of quercetin and vitamin E on egg production, egg quality, and immunity in aging breeder hens

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