Pathogenesis of drug-induced liver injury: Current understanding and future needs

The risk factors for drug-induced liver injury (DILI) involve host factors (including general non-genetic factors and idiosyncratic genetic and immune factors), drug-related factors, and environmental factors. The pathogenesis of DILI can be classified as intrinsic (or direct) hepatotoxicity, idiosy...

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Autor principal:	YU Yuecheng
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Clinical Hepatology 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/77f505c9685d4851bc56f2473b54a49e
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spelling	oai:doaj.org-article:77f505c9685d4851bc56f2473b54a49e2021-11-17T10:35:20ZPathogenesis of drug-induced liver injury: Current understanding and future needs1001-5256https://doaj.org/article/77f505c9685d4851bc56f2473b54a49e2021-11-01T00:00:00Zhttp://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.11.003https://doaj.org/toc/1001-5256The risk factors for drug-induced liver injury (DILI) involve host factors (including general non-genetic factors and idiosyncratic genetic and immune factors), drug-related factors, and environmental factors. The pathogenesis of DILI can be classified as intrinsic (or direct) hepatotoxicity, idiosyncratic hepatotoxicity, and indirect hepatotoxicity, as well as tumorigenicity and carcinogenicity of some drugs to the liver. The pathogenesis of different types of hepatotoxicity not only has significant differences, but also has internal correlation at multiple links. The three-step model centered on mitochondrial permeability transition (MPT) and a two-stage model with liver cell regeneration and liver tissue repair capacity as the determinants of different outcomes display the mechanism progress of DILI from different perspectives. Clarification of the complex pathogenesis of DILI needs long-term collection of clinical cases and systematic studies, which is of great significance for the scientific prevention, diagnosis, and treatment of DILI.YU YuechengEditorial Department of Journal of Clinical HepatologyarticleDiseases of the digestive system. GastroenterologyRC799-869ZHLinchuang Gandanbing Zazhi, Vol 37, Iss 11, Pp 2515-2524 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 YU Yuecheng Pathogenesis of drug-induced liver injury: Current understanding and future needs
description	The risk factors for drug-induced liver injury (DILI) involve host factors (including general non-genetic factors and idiosyncratic genetic and immune factors), drug-related factors, and environmental factors. The pathogenesis of DILI can be classified as intrinsic (or direct) hepatotoxicity, idiosyncratic hepatotoxicity, and indirect hepatotoxicity, as well as tumorigenicity and carcinogenicity of some drugs to the liver. The pathogenesis of different types of hepatotoxicity not only has significant differences, but also has internal correlation at multiple links. The three-step model centered on mitochondrial permeability transition (MPT) and a two-stage model with liver cell regeneration and liver tissue repair capacity as the determinants of different outcomes display the mechanism progress of DILI from different perspectives. Clarification of the complex pathogenesis of DILI needs long-term collection of clinical cases and systematic studies, which is of great significance for the scientific prevention, diagnosis, and treatment of DILI.
format	article
author	YU Yuecheng
author_facet	YU Yuecheng
author_sort	YU Yuecheng
title	Pathogenesis of drug-induced liver injury: Current understanding and future needs
title_short	Pathogenesis of drug-induced liver injury: Current understanding and future needs
title_full	Pathogenesis of drug-induced liver injury: Current understanding and future needs
title_fullStr	Pathogenesis of drug-induced liver injury: Current understanding and future needs
title_full_unstemmed	Pathogenesis of drug-induced liver injury: Current understanding and future needs
title_sort	pathogenesis of drug-induced liver injury: current understanding and future needs
publisher	Editorial Department of Journal of Clinical Hepatology
publishDate	2021
url	https://doaj.org/article/77f505c9685d4851bc56f2473b54a49e
work_keys_str_mv	AT yuyuecheng pathogenesisofdruginducedliverinjurycurrentunderstandingandfutureneeds
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Pathogenesis of drug-induced liver injury: Current understanding and future needs

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