Nuclear lamina dysfunction triggers a germline stem cell checkpoint

Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that...

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Autores principales: Lacy J. Barton, Tingting Duan, Wenfan Ke, Amy Luttinger, Kaylee E. Lovander, Alexey A. Soshnev, Pamela K. Geyer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d
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Sumario:Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.