Nuclear lamina dysfunction triggers a germline stem cell checkpoint
Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that...
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Nature Portfolio
2018
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oai:doaj.org-article:77f7379f13f0473c98fba6ad22b1aa9d2021-12-02T17:31:30ZNuclear lamina dysfunction triggers a germline stem cell checkpoint10.1038/s41467-018-06277-z2041-1723https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06277-zhttps://doaj.org/toc/2041-1723Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.Lacy J. BartonTingting DuanWenfan KeAmy LuttingerKaylee E. LovanderAlexey A. SoshnevPamela K. GeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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Science Q Lacy J. Barton Tingting Duan Wenfan Ke Amy Luttinger Kaylee E. Lovander Alexey A. Soshnev Pamela K. Geyer Nuclear lamina dysfunction triggers a germline stem cell checkpoint |
description |
Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation. |
format |
article |
author |
Lacy J. Barton Tingting Duan Wenfan Ke Amy Luttinger Kaylee E. Lovander Alexey A. Soshnev Pamela K. Geyer |
author_facet |
Lacy J. Barton Tingting Duan Wenfan Ke Amy Luttinger Kaylee E. Lovander Alexey A. Soshnev Pamela K. Geyer |
author_sort |
Lacy J. Barton |
title |
Nuclear lamina dysfunction triggers a germline stem cell checkpoint |
title_short |
Nuclear lamina dysfunction triggers a germline stem cell checkpoint |
title_full |
Nuclear lamina dysfunction triggers a germline stem cell checkpoint |
title_fullStr |
Nuclear lamina dysfunction triggers a germline stem cell checkpoint |
title_full_unstemmed |
Nuclear lamina dysfunction triggers a germline stem cell checkpoint |
title_sort |
nuclear lamina dysfunction triggers a germline stem cell checkpoint |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d |
work_keys_str_mv |
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_version_ |
1718380560867393536 |