Nuclear lamina dysfunction triggers a germline stem cell checkpoint

Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lacy J. Barton, Tingting Duan, Wenfan Ke, Amy Luttinger, Kaylee E. Lovander, Alexey A. Soshnev, Pamela K. Geyer
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:77f7379f13f0473c98fba6ad22b1aa9d
record_format	dspace
spelling	oai:doaj.org-article:77f7379f13f0473c98fba6ad22b1aa9d2021-12-02T17:31:30ZNuclear lamina dysfunction triggers a germline stem cell checkpoint10.1038/s41467-018-06277-z2041-1723https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06277-zhttps://doaj.org/toc/2041-1723Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.Lacy J. BartonTingting DuanWenfan KeAmy LuttingerKaylee E. LovanderAlexey A. SoshnevPamela K. GeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lacy J. Barton Tingting Duan Wenfan Ke Amy Luttinger Kaylee E. Lovander Alexey A. Soshnev Pamela K. Geyer Nuclear lamina dysfunction triggers a germline stem cell checkpoint
description	Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.
format	article
author	Lacy J. Barton Tingting Duan Wenfan Ke Amy Luttinger Kaylee E. Lovander Alexey A. Soshnev Pamela K. Geyer
author_facet	Lacy J. Barton Tingting Duan Wenfan Ke Amy Luttinger Kaylee E. Lovander Alexey A. Soshnev Pamela K. Geyer
author_sort	Lacy J. Barton
title	Nuclear lamina dysfunction triggers a germline stem cell checkpoint
title_short	Nuclear lamina dysfunction triggers a germline stem cell checkpoint
title_full	Nuclear lamina dysfunction triggers a germline stem cell checkpoint
title_fullStr	Nuclear lamina dysfunction triggers a germline stem cell checkpoint
title_full_unstemmed	Nuclear lamina dysfunction triggers a germline stem cell checkpoint
title_sort	nuclear lamina dysfunction triggers a germline stem cell checkpoint
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d
work_keys_str_mv	AT lacyjbarton nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint AT tingtingduan nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint AT wenfanke nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint AT amyluttinger nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint AT kayleeelovander nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint AT alexeyasoshnev nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint AT pamelakgeyer nuclearlaminadysfunctiontriggersagermlinestemcellcheckpoint
_version_	1718380560867393536

Nuclear lamina dysfunction triggers a germline stem cell checkpoint

Similar Items