The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia

Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and progenitor cells.

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Autores principales:	Alessandro Di Tullio, Kevin Rouault-Pierre, Ander Abarrategi, Syed Mian, William Grey, John Gribben, Aengus Stewart, Elizabeth Blackwood, Dominique Bonnet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77ff00f53b1049f3aa2acb231a637d78
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spelling	oai:doaj.org-article:77ff00f53b1049f3aa2acb231a637d782021-12-02T14:41:08ZThe combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia10.1038/s41467-017-01834-42041-1723https://doaj.org/article/77ff00f53b1049f3aa2acb231a637d782017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01834-4https://doaj.org/toc/2041-1723Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and progenitor cells.Alessandro Di TullioKevin Rouault-PierreAnder AbarrategiSyed MianWilliam GreyJohn GribbenAengus StewartElizabeth BlackwoodDominique BonnetNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Di Tullio Kevin Rouault-Pierre Ander Abarrategi Syed Mian William Grey John Gribben Aengus Stewart Elizabeth Blackwood Dominique Bonnet The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
description	Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and progenitor cells.
format	article
author	Alessandro Di Tullio Kevin Rouault-Pierre Ander Abarrategi Syed Mian William Grey John Gribben Aengus Stewart Elizabeth Blackwood Dominique Bonnet
author_facet	Alessandro Di Tullio Kevin Rouault-Pierre Ander Abarrategi Syed Mian William Grey John Gribben Aengus Stewart Elizabeth Blackwood Dominique Bonnet
author_sort	Alessandro Di Tullio
title	The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
title_short	The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
title_full	The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
title_fullStr	The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
title_full_unstemmed	The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
title_sort	combination of chk1 inhibitor with g-csf overrides cytarabine resistance in human acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/77ff00f53b1049f3aa2acb231a637d78
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The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia

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