Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating dynamic euchromatin lamina-associated domains (eLA...

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Autores principales:	Laura Pascual-Reguant, Enrique Blanco, Silvia Galan, François Le Dily, Yasmina Cuartero, Gemma Serra-Bardenys, Valerio Di Carlo, Ane Iturbide, Joan Pau Cebrià-Costa, Lara Nonell, Antonio García de Herreros, Luciano Di Croce, Marc A. Marti-Renom, Sandra Peiró
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78004395e63b43cd90af855de0989ca6
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spelling	oai:doaj.org-article:78004395e63b43cd90af855de0989ca62021-12-02T14:39:47ZLamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains10.1038/s41467-018-05912-z2041-1723https://doaj.org/article/78004395e63b43cd90af855de0989ca62018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05912-zhttps://doaj.org/toc/2041-1723Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating dynamic euchromatin lamina-associated domains (eLADs) during epithelial-to-mesenchymal transition.Laura Pascual-ReguantEnrique BlancoSilvia GalanFrançois Le DilyYasmina CuarteroGemma Serra-BardenysValerio Di CarloAne IturbideJoan Pau Cebrià-CostaLara NonellAntonio García de HerrerosLuciano Di CroceMarc A. Marti-RenomSandra PeiróNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Pascual-Reguant Enrique Blanco Silvia Galan François Le Dily Yasmina Cuartero Gemma Serra-Bardenys Valerio Di Carlo Ane Iturbide Joan Pau Cebrià-Costa Lara Nonell Antonio García de Herreros Luciano Di Croce Marc A. Marti-Renom Sandra Peiró Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
description	Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating dynamic euchromatin lamina-associated domains (eLADs) during epithelial-to-mesenchymal transition.
format	article
author	Laura Pascual-Reguant Enrique Blanco Silvia Galan François Le Dily Yasmina Cuartero Gemma Serra-Bardenys Valerio Di Carlo Ane Iturbide Joan Pau Cebrià-Costa Lara Nonell Antonio García de Herreros Luciano Di Croce Marc A. Marti-Renom Sandra Peiró
author_facet	Laura Pascual-Reguant Enrique Blanco Silvia Galan François Le Dily Yasmina Cuartero Gemma Serra-Bardenys Valerio Di Carlo Ane Iturbide Joan Pau Cebrià-Costa Lara Nonell Antonio García de Herreros Luciano Di Croce Marc A. Marti-Renom Sandra Peiró
author_sort	Laura Pascual-Reguant
title	Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
title_short	Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
title_full	Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
title_fullStr	Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
title_full_unstemmed	Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
title_sort	lamin b1 mapping reveals the existence of dynamic and functional euchromatin lamin b1 domains
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78004395e63b43cd90af855de0989ca6
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Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

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