Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA

The HECT-like E3 ligase SopA inSalmonellahas been suggested to activate host RING ligases TRIM56 and TRIM65. Here, the authors use mass spectrometry, crystal structures and biochemistry to examine the interactions between these proteins in detail.

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Autores principales:	Evgenij Fiskin, Sagar Bhogaraju, Lina Herhaus, Sissy Kalayil, Marcel Hahn, Ivan Dikic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78042980b2f648278c555491f0992e50
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spelling	oai:doaj.org-article:78042980b2f648278c555491f0992e502021-12-02T14:41:58ZStructural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA10.1038/ncomms140042041-1723https://doaj.org/article/78042980b2f648278c555491f0992e502017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14004https://doaj.org/toc/2041-1723The HECT-like E3 ligase SopA inSalmonellahas been suggested to activate host RING ligases TRIM56 and TRIM65. Here, the authors use mass spectrometry, crystal structures and biochemistry to examine the interactions between these proteins in detail.Evgenij FiskinSagar BhogarajuLina HerhausSissy KalayilMarcel HahnIvan DikicNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evgenij Fiskin Sagar Bhogaraju Lina Herhaus Sissy Kalayil Marcel Hahn Ivan Dikic Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA
description	The HECT-like E3 ligase SopA inSalmonellahas been suggested to activate host RING ligases TRIM56 and TRIM65. Here, the authors use mass spectrometry, crystal structures and biochemistry to examine the interactions between these proteins in detail.
format	article
author	Evgenij Fiskin Sagar Bhogaraju Lina Herhaus Sissy Kalayil Marcel Hahn Ivan Dikic
author_facet	Evgenij Fiskin Sagar Bhogaraju Lina Herhaus Sissy Kalayil Marcel Hahn Ivan Dikic
author_sort	Evgenij Fiskin
title	Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA
title_short	Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA
title_full	Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA
title_fullStr	Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA
title_full_unstemmed	Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA
title_sort	structural basis for the recognition and degradation of host trim proteins by salmonella effector sopa
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78042980b2f648278c555491f0992e50
work_keys_str_mv	AT evgenijfiskin structuralbasisfortherecognitionanddegradationofhosttrimproteinsbysalmonellaeffectorsopa AT sagarbhogaraju structuralbasisfortherecognitionanddegradationofhosttrimproteinsbysalmonellaeffectorsopa AT linaherhaus structuralbasisfortherecognitionanddegradationofhosttrimproteinsbysalmonellaeffectorsopa AT sissykalayil structuralbasisfortherecognitionanddegradationofhosttrimproteinsbysalmonellaeffectorsopa AT marcelhahn structuralbasisfortherecognitionanddegradationofhosttrimproteinsbysalmonellaeffectorsopa AT ivandikic structuralbasisfortherecognitionanddegradationofhosttrimproteinsbysalmonellaeffectorsopa
_version_	1718389816379310080

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA

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