Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA

The HECT-like E3 ligase SopA inSalmonellahas been suggested to activate host RING ligases TRIM56 and TRIM65. Here, the authors use mass spectrometry, crystal structures and biochemistry to examine the interactions between these proteins in detail.

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Autores principales: Evgenij Fiskin, Sagar Bhogaraju, Lina Herhaus, Sissy Kalayil, Marcel Hahn, Ivan Dikic
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/78042980b2f648278c555491f0992e50
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