Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production....
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Nature Portfolio
2018
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oai:doaj.org-article:7804d6d1ead34e479941b57f992bcb622021-12-02T14:39:47ZArf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe10.1038/s41467-018-05087-72041-1723https://doaj.org/article/7804d6d1ead34e479941b57f992bcb622018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05087-7https://doaj.org/toc/2041-1723Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production.Yasuhito OnoderaJin-Min NamMei HorikawaHiroki ShiratoHisataka SabeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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Science Q Yasuhito Onodera Jin-Min Nam Mei Horikawa Hiroki Shirato Hisataka Sabe Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
description |
Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production. |
format |
article |
author |
Yasuhito Onodera Jin-Min Nam Mei Horikawa Hiroki Shirato Hisataka Sabe |
author_facet |
Yasuhito Onodera Jin-Min Nam Mei Horikawa Hiroki Shirato Hisataka Sabe |
author_sort |
Yasuhito Onodera |
title |
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
title_short |
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
title_full |
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
title_fullStr |
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
title_full_unstemmed |
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
title_sort |
arf6-driven cell invasion is intrinsically linked to trak1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/7804d6d1ead34e479941b57f992bcb62 |
work_keys_str_mv |
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_version_ |
1718390480814735360 |