Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe

Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production....

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Auteurs principaux: Yasuhito Onodera, Jin-Min Nam, Mei Horikawa, Hiroki Shirato, Hisataka Sabe
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/7804d6d1ead34e479941b57f992bcb62
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spelling oai:doaj.org-article:7804d6d1ead34e479941b57f992bcb622021-12-02T14:39:47ZArf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe10.1038/s41467-018-05087-72041-1723https://doaj.org/article/7804d6d1ead34e479941b57f992bcb622018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05087-7https://doaj.org/toc/2041-1723Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production.Yasuhito OnoderaJin-Min NamMei HorikawaHiroki ShiratoHisataka SabeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yasuhito Onodera
Jin-Min Nam
Mei Horikawa
Hiroki Shirato
Hisataka Sabe
Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
description Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production.
format article
author Yasuhito Onodera
Jin-Min Nam
Mei Horikawa
Hiroki Shirato
Hisataka Sabe
author_facet Yasuhito Onodera
Jin-Min Nam
Mei Horikawa
Hiroki Shirato
Hisataka Sabe
author_sort Yasuhito Onodera
title Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
title_short Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
title_full Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
title_fullStr Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
title_full_unstemmed Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
title_sort arf6-driven cell invasion is intrinsically linked to trak1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/7804d6d1ead34e479941b57f992bcb62
work_keys_str_mv AT yasuhitoonodera arf6drivencellinvasionisintrinsicallylinkedtotrak1mediatedmitochondrialanterogradetraffickingtoavoidoxidativecatastrophe
AT jinminnam arf6drivencellinvasionisintrinsicallylinkedtotrak1mediatedmitochondrialanterogradetraffickingtoavoidoxidativecatastrophe
AT meihorikawa arf6drivencellinvasionisintrinsicallylinkedtotrak1mediatedmitochondrialanterogradetraffickingtoavoidoxidativecatastrophe
AT hirokishirato arf6drivencellinvasionisintrinsicallylinkedtotrak1mediatedmitochondrialanterogradetraffickingtoavoidoxidativecatastrophe
AT hisatakasabe arf6drivencellinvasionisintrinsicallylinkedtotrak1mediatedmitochondrialanterogradetraffickingtoavoidoxidativecatastrophe
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