Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration

Shue Jin,1 Jidong Li,1 Jian Wang,1 Jiaxing Jiang,1 Yi Zuo,1 Yubao Li,1 Fang Yang2 1Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China; 2Department of Biomaterials, Radboud University Medical Center, Nijmegen, the Netherlands Purpose: The...

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Autores principales:	Jin S, Li J, Wang J, Jiang J, Zuo Y, Li Y, Yang F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	antimicrobial electrospinning chitosan membrane guided bone regeneration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7805ea4f26af467d9a38f89f071339aa
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spelling	oai:doaj.org-article:7805ea4f26af467d9a38f89f071339aa2021-12-02T00:24:07ZElectrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration1178-2013https://doaj.org/article/7805ea4f26af467d9a38f89f071339aa2018-08-01T00:00:00Zhttps://www.dovepress.com/electrospun-silver-ion-loaded-calcium-phosphatechitosan-antibacterial--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shue Jin,1 Jidong Li,1 Jian Wang,1 Jiaxing Jiang,1 Yi Zuo,1 Yubao Li,1 Fang Yang2 1Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China; 2Department of Biomaterials, Radboud University Medical Center, Nijmegen, the Netherlands Purpose: The purpose of this study is to construct a guided bone regeneration membrane that is similar to bone components and structurally resembles the native extracellular matrix with sufficient antibacterial properties.Materials and methods: A novel type of biomimetic and bioactive silver ion-loaded calcium phosphate/chitosan (Ag-CaP/CS) membrane with antibacterial ability was successfully developed by incorporation of silver ion-loaded CaP via a one-step electrospinning method and subsequently crosslinked with vanillin.Results: Evaluation of the physicochemical properties revealed that the fabricated fibrous membranes mimicked the extracellular matrix structure and the addition of CaP significantly increased the mineralization ability of the membranes. Importantly, the Ag-CaP/CS membranes exhibited a sustainable release of Ag+, which in turn inhibited the adhesion and growth of Staphylococcus mutans. The results of cell adhesion and MTT assay revealed that the Ag-CaP/CS membranes were cytocompatible with bone marrow stromal cells.Conclusion: The fabricated electrospinning Ag-CaP/CS nanofiber membranes with excellent biocompatibility and strong antimicrobial properties have great potential to be used for guided bone regeneration. Keywords: antimicrobial, electrospinning, chitosan, membrane, guided bone regenerationJin SLi JWang JJiang JZuo YLi YYang FDove Medical Pressarticleantimicrobialelectrospinningchitosanmembraneguided bone regenerationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 4591-4605 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial electrospinning chitosan membrane guided bone regeneration Medicine (General) R5-920
spellingShingle	antimicrobial electrospinning chitosan membrane guided bone regeneration Medicine (General) R5-920 Jin S Li J Wang J Jiang J Zuo Y Li Y Yang F Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
description	Shue Jin,1 Jidong Li,1 Jian Wang,1 Jiaxing Jiang,1 Yi Zuo,1 Yubao Li,1 Fang Yang2 1Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China; 2Department of Biomaterials, Radboud University Medical Center, Nijmegen, the Netherlands Purpose: The purpose of this study is to construct a guided bone regeneration membrane that is similar to bone components and structurally resembles the native extracellular matrix with sufficient antibacterial properties.Materials and methods: A novel type of biomimetic and bioactive silver ion-loaded calcium phosphate/chitosan (Ag-CaP/CS) membrane with antibacterial ability was successfully developed by incorporation of silver ion-loaded CaP via a one-step electrospinning method and subsequently crosslinked with vanillin.Results: Evaluation of the physicochemical properties revealed that the fabricated fibrous membranes mimicked the extracellular matrix structure and the addition of CaP significantly increased the mineralization ability of the membranes. Importantly, the Ag-CaP/CS membranes exhibited a sustainable release of Ag+, which in turn inhibited the adhesion and growth of Staphylococcus mutans. The results of cell adhesion and MTT assay revealed that the Ag-CaP/CS membranes were cytocompatible with bone marrow stromal cells.Conclusion: The fabricated electrospinning Ag-CaP/CS nanofiber membranes with excellent biocompatibility and strong antimicrobial properties have great potential to be used for guided bone regeneration. Keywords: antimicrobial, electrospinning, chitosan, membrane, guided bone regeneration
format	article
author	Jin S Li J Wang J Jiang J Zuo Y Li Y Yang F
author_facet	Jin S Li J Wang J Jiang J Zuo Y Li Y Yang F
author_sort	Jin S
title	Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
title_short	Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
title_full	Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
title_fullStr	Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
title_full_unstemmed	Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
title_sort	electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7805ea4f26af467d9a38f89f071339aa
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Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration

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