Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation

Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interac...

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Autores principales:	A. Manuel Liaci, Friedrich Förster
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	signal peptide signal peptidase ER translocon endoplasmic reticulum protein targeting chaperones Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7809aa2c4b524298afeb574ef8141eda
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spelling	oai:doaj.org-article:7809aa2c4b524298afeb574ef8141eda2021-11-11T17:17:37ZTake Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation10.3390/ijms2221118711422-00671661-6596https://doaj.org/article/7809aa2c4b524298afeb574ef8141eda2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11871https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interactions between the signal sequences and the various ER targeting and translocation machineries such as the signal recognition particle (SRP), the protein-conducting channel Sec61, and the signal peptidase complex (SPC) that determine the proteins’ target location and provide translocation fidelity. In this review, we follow the signal peptide into the ER and discuss the recent insights that structural biology has provided on the governing principles of those interactions.A. Manuel LiaciFriedrich FörsterMDPI AGarticlesignal peptidesignal peptidaseER transloconendoplasmic reticulumprotein targetingchaperonesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11871, p 11871 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	signal peptide signal peptidase ER translocon endoplasmic reticulum protein targeting chaperones Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	signal peptide signal peptidase ER translocon endoplasmic reticulum protein targeting chaperones Biology (General) QH301-705.5 Chemistry QD1-999 A. Manuel Liaci Friedrich Förster Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
description	Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable signal sequences target roughly a quarter of the human proteome to the ER. These short peptides, mostly located at the N-termini of proteins, are highly diverse. For most proteins targeted to the ER, it is the interactions between the signal sequences and the various ER targeting and translocation machineries such as the signal recognition particle (SRP), the protein-conducting channel Sec61, and the signal peptidase complex (SPC) that determine the proteins’ target location and provide translocation fidelity. In this review, we follow the signal peptide into the ER and discuss the recent insights that structural biology has provided on the governing principles of those interactions.
format	article
author	A. Manuel Liaci Friedrich Förster
author_facet	A. Manuel Liaci Friedrich Förster
author_sort	A. Manuel Liaci
title	Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
title_short	Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
title_full	Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
title_fullStr	Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
title_full_unstemmed	Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation
title_sort	take me home, protein roads: structural insights into signal peptide interactions during er translocation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7809aa2c4b524298afeb574ef8141eda
work_keys_str_mv	AT amanuelliaci takemehomeproteinroadsstructuralinsightsintosignalpeptideinteractionsduringertranslocation AT friedrichforster takemehomeproteinroadsstructuralinsightsintosignalpeptideinteractionsduringertranslocation
_version_	1718432125761355776

Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation

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