Hydrophobic gating in BK channels

BK channels are regulated by membrane voltage and intracellular Ca2+ but the structural features that block the ion flow in the closed state remain unknown. Here authors use molecular dynamics simulation and show that a physical gate is not required; instead ion flow is regulated by hydrophobic dewe...

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Autores principales:	Zhiguang Jia, Mahdieh Yazdani, Guohui Zhang, Jianmin Cui, Jianhan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/780a4ba56ad34fc58c8da32e6b0a5109
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spelling	oai:doaj.org-article:780a4ba56ad34fc58c8da32e6b0a51092021-12-02T17:31:13ZHydrophobic gating in BK channels10.1038/s41467-018-05970-32041-1723https://doaj.org/article/780a4ba56ad34fc58c8da32e6b0a51092018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05970-3https://doaj.org/toc/2041-1723BK channels are regulated by membrane voltage and intracellular Ca2+ but the structural features that block the ion flow in the closed state remain unknown. Here authors use molecular dynamics simulation and show that a physical gate is not required; instead ion flow is regulated by hydrophobic dewetting due to changes in pore shape and surface hydrophobicity.Zhiguang JiaMahdieh YazdaniGuohui ZhangJianmin CuiJianhan ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiguang Jia Mahdieh Yazdani Guohui Zhang Jianmin Cui Jianhan Chen Hydrophobic gating in BK channels
description	BK channels are regulated by membrane voltage and intracellular Ca2+ but the structural features that block the ion flow in the closed state remain unknown. Here authors use molecular dynamics simulation and show that a physical gate is not required; instead ion flow is regulated by hydrophobic dewetting due to changes in pore shape and surface hydrophobicity.
format	article
author	Zhiguang Jia Mahdieh Yazdani Guohui Zhang Jianmin Cui Jianhan Chen
author_facet	Zhiguang Jia Mahdieh Yazdani Guohui Zhang Jianmin Cui Jianhan Chen
author_sort	Zhiguang Jia
title	Hydrophobic gating in BK channels
title_short	Hydrophobic gating in BK channels
title_full	Hydrophobic gating in BK channels
title_fullStr	Hydrophobic gating in BK channels
title_full_unstemmed	Hydrophobic gating in BK channels
title_sort	hydrophobic gating in bk channels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/780a4ba56ad34fc58c8da32e6b0a5109
work_keys_str_mv	AT zhiguangjia hydrophobicgatinginbkchannels AT mahdiehyazdani hydrophobicgatinginbkchannels AT guohuizhang hydrophobicgatinginbkchannels AT jianmincui hydrophobicgatinginbkchannels AT jianhanchen hydrophobicgatinginbkchannels
_version_	1718380680552906752

Hydrophobic gating in BK channels

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