Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis

Abstract Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA associ...

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Autores principales:	Marcos Papais Alvarenga, Luciana Ferreira do Carmo, Claudia Cristina Ferreira Vasconcelos, Marina Papais Alvarenga, Helcio Alvarenga-Filho, Cleonice Alves de Melo Bento, Carmen Lucia Antão Paiva, Laura Leyva-Fernández, Óscar Fernández, Regina Maria Papais-Alvarenga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/780a5ddcc22b4e3ea7650035a82f2f45
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spelling	oai:doaj.org-article:780a5ddcc22b4e3ea7650035a82f2f452021-12-02T15:12:52ZNeuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis10.1038/s41598-020-80535-32045-2322https://doaj.org/article/780a5ddcc22b4e3ea7650035a82f2f452021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80535-3https://doaj.org/toc/2045-2322Abstract Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB103 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB103:01 allele in Western populations and with the DPB105:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB103 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.Marcos Papais AlvarengaLuciana Ferreira do CarmoClaudia Cristina Ferreira VasconcelosMarina Papais AlvarengaHelcio Alvarenga-FilhoCleonice Alves de Melo BentoCarmen Lucia Antão PaivaLaura Leyva-FernándezÓscar FernándezRegina Maria Papais-AlvarengaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcos Papais Alvarenga Luciana Ferreira do Carmo Claudia Cristina Ferreira Vasconcelos Marina Papais Alvarenga Helcio Alvarenga-Filho Cleonice Alves de Melo Bento Carmen Lucia Antão Paiva Laura Leyva-Fernández Óscar Fernández Regina Maria Papais-Alvarenga Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis
description	Abstract Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB103 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB103:01 allele in Western populations and with the DPB105:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB103 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.
format	article
author	Marcos Papais Alvarenga Luciana Ferreira do Carmo Claudia Cristina Ferreira Vasconcelos Marina Papais Alvarenga Helcio Alvarenga-Filho Cleonice Alves de Melo Bento Carmen Lucia Antão Paiva Laura Leyva-Fernández Óscar Fernández Regina Maria Papais-Alvarenga
author_facet	Marcos Papais Alvarenga Luciana Ferreira do Carmo Claudia Cristina Ferreira Vasconcelos Marina Papais Alvarenga Helcio Alvarenga-Filho Cleonice Alves de Melo Bento Carmen Lucia Antão Paiva Laura Leyva-Fernández Óscar Fernández Regina Maria Papais-Alvarenga
author_sort	Marcos Papais Alvarenga
title	Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis
title_short	Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis
title_full	Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis
title_fullStr	Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis
title_full_unstemmed	Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis
title_sort	neuromyelitis optica is an hla associated disease different from multiple sclerosis: a systematic review with meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/780a5ddcc22b4e3ea7650035a82f2f45
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Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis

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