Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion

Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion

Haruto Katahira,1 Masataka Sunagawa,1 Daishi Watanabe,1,2 Yasuaki Kanada,1,3 Ayami Katayama,1 Risa Yamauchi,1 Masashi Takashima,4 Shintaro Ishikawa,1 Tadashi Hisamitsu1 1Department of Physiology, 2Department of Neurology, School of Medicine, Showa University, 3Department of Surgery, Showa Universit...

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Autores principales: Katahira H, Sunagawa M, Watanabe D, Kanada Y, Katayama A, Yamauchi R, Takashima M, Ishikawa S, Hisamitsu T
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Yokukansan
orexin
anti-stress effect
social isolation stress
corticosterone
aggressive behavior
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/780d5d6ff5e544309f2ee0135f409148
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spelling oai:doaj.org-article:780d5d6ff5e544309f2ee0135f4091482021-12-02T03:35:23ZAntistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion1178-2021https://doaj.org/article/780d5d6ff5e544309f2ee0135f4091482017-03-01T00:00:00Zhttps://www.dovepress.com/antistress-effects-of-kampo-medicine-quotyokukansanquot-via-regulation-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Haruto Katahira,1 Masataka Sunagawa,1 Daishi Watanabe,1,2 Yasuaki Kanada,1,3 Ayami Katayama,1 Risa Yamauchi,1 Masashi Takashima,4 Shintaro Ishikawa,1 Tadashi Hisamitsu1 1Department of Physiology, 2Department of Neurology, School of Medicine, Showa University, 3Department of Surgery, Showa University Koto Toyosu Hospital, Tokyo, 4Department of Orthopaedic Surgery, Showa University Fujigaoka Hospital, Kanagawa, Japan Objective: Various stressors induce stress responses through the hypothalamic–pituitary–adrenal and the sympathetic–adrenal–medullary axes, which are regulated, in part, by orexin. For example, secretion of orexin in the hypothalamus is increased in rats exposed to the stress of social isolation for 1 week. In this study, the antistress effects of Kampo medicine Yokukansan (YKS) via the regulation of orexin secretion were investigated using a rat model.Methods and results: The administration of 300 mg/kg per day of YKS to rats for 1 week significantly decreased the plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin levels. Therefore, 300 mg/kg of YKS was an effective dose for controlling orexin secretion. Subsequently, rats were divided into group-housed control (Con), individually housed stress (Stress), and individually housed YKS (300 mg/kg)-treated stress (Stress + YKS) groups. After 1 week, a resident–intruder aggression test was performed, and the plasma levels of orexin and corticosterone were measured. In the Stress group, aggressive behavior and the levels of corticosterone and orexin significantly increased compared with the Con group; however, these effects were inhibited in the Stress + YKS group. Further, an orexin receptor antagonist (TCS 1102; 10 mg/kg) was intraperitoneally administered to rats exposed to isolation stress to determine whether orexin was involved in stress responses. Under these conditions, aggressive behavior and the level of corticosterone significantly decreased compared with the Stress group.Conclusion: These results suggest that orexin is involved in the control of stress response and that YKS exerts an antistress effect via the regulation of orexin secretion. Keywords: Yokukansan, orexin, antistress effect, social isolation stress, corticosterone, aggressive behaviorKatahira HSunagawa MWatanabe DKanada YKatayama AYamauchi RTakashima MIshikawa SHisamitsu TDove Medical PressarticleYokukansanorexinanti-stress effectsocial isolation stresscorticosteroneaggressive behaviorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 863-872 (2017)
institution DOAJ
collection DOAJ
language EN
topic Yokukansan
orexin
anti-stress effect
social isolation stress
corticosterone
aggressive behavior
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Yokukansan
orexin
anti-stress effect
social isolation stress
corticosterone
aggressive behavior
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Katahira H
Sunagawa M
Watanabe D
Kanada Y
Katayama A
Yamauchi R
Takashima M
Ishikawa S
Hisamitsu T
Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
description Haruto Katahira,1 Masataka Sunagawa,1 Daishi Watanabe,1,2 Yasuaki Kanada,1,3 Ayami Katayama,1 Risa Yamauchi,1 Masashi Takashima,4 Shintaro Ishikawa,1 Tadashi Hisamitsu1 1Department of Physiology, 2Department of Neurology, School of Medicine, Showa University, 3Department of Surgery, Showa University Koto Toyosu Hospital, Tokyo, 4Department of Orthopaedic Surgery, Showa University Fujigaoka Hospital, Kanagawa, Japan Objective: Various stressors induce stress responses through the hypothalamic–pituitary–adrenal and the sympathetic–adrenal–medullary axes, which are regulated, in part, by orexin. For example, secretion of orexin in the hypothalamus is increased in rats exposed to the stress of social isolation for 1 week. In this study, the antistress effects of Kampo medicine Yokukansan (YKS) via the regulation of orexin secretion were investigated using a rat model.Methods and results: The administration of 300 mg/kg per day of YKS to rats for 1 week significantly decreased the plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin levels. Therefore, 300 mg/kg of YKS was an effective dose for controlling orexin secretion. Subsequently, rats were divided into group-housed control (Con), individually housed stress (Stress), and individually housed YKS (300 mg/kg)-treated stress (Stress + YKS) groups. After 1 week, a resident–intruder aggression test was performed, and the plasma levels of orexin and corticosterone were measured. In the Stress group, aggressive behavior and the levels of corticosterone and orexin significantly increased compared with the Con group; however, these effects were inhibited in the Stress + YKS group. Further, an orexin receptor antagonist (TCS 1102; 10 mg/kg) was intraperitoneally administered to rats exposed to isolation stress to determine whether orexin was involved in stress responses. Under these conditions, aggressive behavior and the level of corticosterone significantly decreased compared with the Stress group.Conclusion: These results suggest that orexin is involved in the control of stress response and that YKS exerts an antistress effect via the regulation of orexin secretion. Keywords: Yokukansan, orexin, antistress effect, social isolation stress, corticosterone, aggressive behavior
format article
author Katahira H
Sunagawa M
Watanabe D
Kanada Y
Katayama A
Yamauchi R
Takashima M
Ishikawa S
Hisamitsu T
author_facet Katahira H
Sunagawa M
Watanabe D
Kanada Y
Katayama A
Yamauchi R
Takashima M
Ishikawa S
Hisamitsu T
author_sort Katahira H
title Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
title_short Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
title_full Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
title_fullStr Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
title_full_unstemmed Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion
title_sort antistress effects of kampo medicine "yokukansan" via regulation of orexin secretion
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/780d5d6ff5e544309f2ee0135f409148
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