Anti-inflammatory potential of Portuguese thermal waters

Abstract In light of Medical Hydrology, thermal waters (TW) are all-natural mineral waters that emerge inside a thermal resort and have therapeutic applications. Their beneficial effect has been empirically recognized for centuries, being indicated for symptom alleviation and/or treatment of several...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. Silva, A. S. Oliveira, C. V. Vaz, S. Correia, R. Ferreira, L. Breitenfeld, J. Martinez-de-Oliveira, R. Palmeira-de-Oliveira, C. M. F. Pereira, A. Palmeira-de-Oliveira, M. T. Cruz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/780ee287f2ac46c59129c2963a08e0cf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:780ee287f2ac46c59129c2963a08e0cf
record_format	dspace
spelling	oai:doaj.org-article:780ee287f2ac46c59129c2963a08e0cf2021-12-02T13:33:59ZAnti-inflammatory potential of Portuguese thermal waters10.1038/s41598-020-79394-92045-2322https://doaj.org/article/780ee287f2ac46c59129c2963a08e0cf2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79394-9https://doaj.org/toc/2045-2322Abstract In light of Medical Hydrology, thermal waters (TW) are all-natural mineral waters that emerge inside a thermal resort and have therapeutic applications. Their beneficial effect has been empirically recognized for centuries, being indicated for symptom alleviation and/or treatment of several diseases, almost all associated with inflammation. Indeed, an anti-inflammatory effect has been attributed to many different Portuguese TW but there is no scientific validation supporting this empiric knowledge. In the present study, we aimed to investigate the anti-inflammatory properties of 14 TW pertaining to thermal centers located in the Central Region of Portugal, and grouped according to their ionic profile. Mouse macrophage cells stimulated with lipopolysaccharide (LPS), a Toll-like receptor 4 agonist, were exposed to culture medium prepared in TW. Metabolism, nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression levels and the scavenging capacity of TW, were investigated in vitro. 11 out of 14 TW reduced NO production and/or iNOS expression, and/or scavenging activity, in macrophages exposed to LPS. The sulphated/calcic TW did not show any effect on at least one of the inflammatory parameters evaluated. Two sulphurous/bicarbonate/sodic TW and the sulphurous/chlorinated/sodic TW promoted an increase in NO production and/or iNOS expression. Our results validate, for the first time, the anti-inflammatory properties of Portuguese TW, supporting their therapeutic use in the treatment of inflammation-related diseases and promoting their putative application in cosmetic products and medical devices.A. SilvaA. S. OliveiraC. V. VazS. CorreiaR. FerreiraL. BreitenfeldJ. Martinez-de-OliveiraR. Palmeira-de-OliveiraC. M. F. PereiraA. Palmeira-de-OliveiraM. T. CruzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Silva A. S. Oliveira C. V. Vaz S. Correia R. Ferreira L. Breitenfeld J. Martinez-de-Oliveira R. Palmeira-de-Oliveira C. M. F. Pereira A. Palmeira-de-Oliveira M. T. Cruz Anti-inflammatory potential of Portuguese thermal waters
description	Abstract In light of Medical Hydrology, thermal waters (TW) are all-natural mineral waters that emerge inside a thermal resort and have therapeutic applications. Their beneficial effect has been empirically recognized for centuries, being indicated for symptom alleviation and/or treatment of several diseases, almost all associated with inflammation. Indeed, an anti-inflammatory effect has been attributed to many different Portuguese TW but there is no scientific validation supporting this empiric knowledge. In the present study, we aimed to investigate the anti-inflammatory properties of 14 TW pertaining to thermal centers located in the Central Region of Portugal, and grouped according to their ionic profile. Mouse macrophage cells stimulated with lipopolysaccharide (LPS), a Toll-like receptor 4 agonist, were exposed to culture medium prepared in TW. Metabolism, nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression levels and the scavenging capacity of TW, were investigated in vitro. 11 out of 14 TW reduced NO production and/or iNOS expression, and/or scavenging activity, in macrophages exposed to LPS. The sulphated/calcic TW did not show any effect on at least one of the inflammatory parameters evaluated. Two sulphurous/bicarbonate/sodic TW and the sulphurous/chlorinated/sodic TW promoted an increase in NO production and/or iNOS expression. Our results validate, for the first time, the anti-inflammatory properties of Portuguese TW, supporting their therapeutic use in the treatment of inflammation-related diseases and promoting their putative application in cosmetic products and medical devices.
format	article
author	A. Silva A. S. Oliveira C. V. Vaz S. Correia R. Ferreira L. Breitenfeld J. Martinez-de-Oliveira R. Palmeira-de-Oliveira C. M. F. Pereira A. Palmeira-de-Oliveira M. T. Cruz
author_facet	A. Silva A. S. Oliveira C. V. Vaz S. Correia R. Ferreira L. Breitenfeld J. Martinez-de-Oliveira R. Palmeira-de-Oliveira C. M. F. Pereira A. Palmeira-de-Oliveira M. T. Cruz
author_sort	A. Silva
title	Anti-inflammatory potential of Portuguese thermal waters
title_short	Anti-inflammatory potential of Portuguese thermal waters
title_full	Anti-inflammatory potential of Portuguese thermal waters
title_fullStr	Anti-inflammatory potential of Portuguese thermal waters
title_full_unstemmed	Anti-inflammatory potential of Portuguese thermal waters
title_sort	anti-inflammatory potential of portuguese thermal waters
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/780ee287f2ac46c59129c2963a08e0cf
work_keys_str_mv	AT asilva antiinflammatorypotentialofportuguesethermalwaters AT asoliveira antiinflammatorypotentialofportuguesethermalwaters AT cvvaz antiinflammatorypotentialofportuguesethermalwaters AT scorreia antiinflammatorypotentialofportuguesethermalwaters AT rferreira antiinflammatorypotentialofportuguesethermalwaters AT lbreitenfeld antiinflammatorypotentialofportuguesethermalwaters AT jmartinezdeoliveira antiinflammatorypotentialofportuguesethermalwaters AT rpalmeiradeoliveira antiinflammatorypotentialofportuguesethermalwaters AT cmfpereira antiinflammatorypotentialofportuguesethermalwaters AT apalmeiradeoliveira antiinflammatorypotentialofportuguesethermalwaters AT mtcruz antiinflammatorypotentialofportuguesethermalwaters
_version_	1718392803343466496

Anti-inflammatory potential of Portuguese thermal waters

Ejemplares similares