Anti-inflammatory potential of Portuguese thermal waters

Abstract In light of Medical Hydrology, thermal waters (TW) are all-natural mineral waters that emerge inside a thermal resort and have therapeutic applications. Their beneficial effect has been empirically recognized for centuries, being indicated for symptom alleviation and/or treatment of several...

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Autores principales: A. Silva, A. S. Oliveira, C. V. Vaz, S. Correia, R. Ferreira, L. Breitenfeld, J. Martinez-de-Oliveira, R. Palmeira-de-Oliveira, C. M. F. Pereira, A. Palmeira-de-Oliveira, M. T. Cruz
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/780ee287f2ac46c59129c2963a08e0cf
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spelling oai:doaj.org-article:780ee287f2ac46c59129c2963a08e0cf2021-12-02T13:33:59ZAnti-inflammatory potential of Portuguese thermal waters10.1038/s41598-020-79394-92045-2322https://doaj.org/article/780ee287f2ac46c59129c2963a08e0cf2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79394-9https://doaj.org/toc/2045-2322Abstract In light of Medical Hydrology, thermal waters (TW) are all-natural mineral waters that emerge inside a thermal resort and have therapeutic applications. Their beneficial effect has been empirically recognized for centuries, being indicated for symptom alleviation and/or treatment of several diseases, almost all associated with inflammation. Indeed, an anti-inflammatory effect has been attributed to many different Portuguese TW but there is no scientific validation supporting this empiric knowledge. In the present study, we aimed to investigate the anti-inflammatory properties of 14 TW pertaining to thermal centers located in the Central Region of Portugal, and grouped according to their ionic profile. Mouse macrophage cells stimulated with lipopolysaccharide (LPS), a Toll-like receptor 4 agonist, were exposed to culture medium prepared in TW. Metabolism, nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression levels and the scavenging capacity of TW, were investigated in vitro. 11 out of 14 TW reduced NO production and/or iNOS expression, and/or scavenging activity, in macrophages exposed to LPS. The sulphated/calcic TW did not show any effect on at least one of the inflammatory parameters evaluated. Two sulphurous/bicarbonate/sodic TW and the sulphurous/chlorinated/sodic TW promoted an increase in NO production and/or iNOS expression. Our results validate, for the first time, the anti-inflammatory properties of Portuguese TW, supporting their therapeutic use in the treatment of inflammation-related diseases and promoting their putative application in cosmetic products and medical devices.A. SilvaA. S. OliveiraC. V. VazS. CorreiaR. FerreiraL. BreitenfeldJ. Martinez-de-OliveiraR. Palmeira-de-OliveiraC. M. F. PereiraA. Palmeira-de-OliveiraM. T. CruzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
A. Silva
A. S. Oliveira
C. V. Vaz
S. Correia
R. Ferreira
L. Breitenfeld
J. Martinez-de-Oliveira
R. Palmeira-de-Oliveira
C. M. F. Pereira
A. Palmeira-de-Oliveira
M. T. Cruz
Anti-inflammatory potential of Portuguese thermal waters
description Abstract In light of Medical Hydrology, thermal waters (TW) are all-natural mineral waters that emerge inside a thermal resort and have therapeutic applications. Their beneficial effect has been empirically recognized for centuries, being indicated for symptom alleviation and/or treatment of several diseases, almost all associated with inflammation. Indeed, an anti-inflammatory effect has been attributed to many different Portuguese TW but there is no scientific validation supporting this empiric knowledge. In the present study, we aimed to investigate the anti-inflammatory properties of 14 TW pertaining to thermal centers located in the Central Region of Portugal, and grouped according to their ionic profile. Mouse macrophage cells stimulated with lipopolysaccharide (LPS), a Toll-like receptor 4 agonist, were exposed to culture medium prepared in TW. Metabolism, nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression levels and the scavenging capacity of TW, were investigated in vitro. 11 out of 14 TW reduced NO production and/or iNOS expression, and/or scavenging activity, in macrophages exposed to LPS. The sulphated/calcic TW did not show any effect on at least one of the inflammatory parameters evaluated. Two sulphurous/bicarbonate/sodic TW and the sulphurous/chlorinated/sodic TW promoted an increase in NO production and/or iNOS expression. Our results validate, for the first time, the anti-inflammatory properties of Portuguese TW, supporting their therapeutic use in the treatment of inflammation-related diseases and promoting their putative application in cosmetic products and medical devices.
format article
author A. Silva
A. S. Oliveira
C. V. Vaz
S. Correia
R. Ferreira
L. Breitenfeld
J. Martinez-de-Oliveira
R. Palmeira-de-Oliveira
C. M. F. Pereira
A. Palmeira-de-Oliveira
M. T. Cruz
author_facet A. Silva
A. S. Oliveira
C. V. Vaz
S. Correia
R. Ferreira
L. Breitenfeld
J. Martinez-de-Oliveira
R. Palmeira-de-Oliveira
C. M. F. Pereira
A. Palmeira-de-Oliveira
M. T. Cruz
author_sort A. Silva
title Anti-inflammatory potential of Portuguese thermal waters
title_short Anti-inflammatory potential of Portuguese thermal waters
title_full Anti-inflammatory potential of Portuguese thermal waters
title_fullStr Anti-inflammatory potential of Portuguese thermal waters
title_full_unstemmed Anti-inflammatory potential of Portuguese thermal waters
title_sort anti-inflammatory potential of portuguese thermal waters
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/780ee287f2ac46c59129c2963a08e0cf
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