Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO

Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supports patients suffering from refractory cardiogenic shock. Thromboembolic complications (TeC) are common in VA-ECMO patients and are associated with increased morbidity and mortality. Valid markers to predict TeC in VA-ECMO pat...

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Autores principales:	Sebastian Roth, Catrin Jansen, René M’Pembele, Alexandra Stroda, Udo Boeken, Payam Akhyari, Artur Lichtenberg, Markus W. Hollmann, Ragnar Huhn, Giovanna Lurati Buse, Hug Aubin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/780f78bfb91b46618d6293c692855c00
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spelling	oai:doaj.org-article:780f78bfb91b46618d6293c692855c002021-12-02T18:51:41ZFibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO10.1038/s41598-021-95689-x2045-2322https://doaj.org/article/780f78bfb91b46618d6293c692855c002021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95689-xhttps://doaj.org/toc/2045-2322Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supports patients suffering from refractory cardiogenic shock. Thromboembolic complications (TeC) are common in VA-ECMO patients and are associated with increased morbidity and mortality. Valid markers to predict TeC in VA-ECMO patients are lacking. The present study investigated the predictive value of baseline Fibrinogen–Albumin-Ratio (FAR) for in-hospital TeC in patients undergoing VA-ECMO. This retrospective cohort study included patients who underwent VA-ECMO therapy due to cardiogenic shock at the University Hospital Duesseldorf, Germany between 2011 and 2018. Main exposure was baseline FAR measured at initiation of VA-ECMO therapy. The primary endpoint was the in-hospital incidence of TeC. In total, 344 patients were included into analysis (74.7% male, mean age 59 ± 14 years). The in-hospital incidence of TeC was 34%. Receiver operating characteristics (ROC) curve of FAR for in-hospital TeC revealed an area under the curve of 0.67 [95% confidence interval (CI) 0.61–0.74]. Youden index determined a cutoff of 130 for baseline FAR. Multivariate logistic regression revealed an adjusted odds-ratio of 3.72 [95% CI 2.26–6.14] for the association between FAR and TeC. Baseline FAR is independently associated with in-hospital TeC in patients undergoing VA-ECMO. Thus, FAR might contribute to the prediction of TeC in this cohort.Sebastian RothCatrin JansenRené M’PembeleAlexandra StrodaUdo BoekenPayam AkhyariArtur LichtenbergMarkus W. HollmannRagnar HuhnGiovanna Lurati BuseHug AubinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastian Roth Catrin Jansen René M’Pembele Alexandra Stroda Udo Boeken Payam Akhyari Artur Lichtenberg Markus W. Hollmann Ragnar Huhn Giovanna Lurati Buse Hug Aubin Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
description	Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supports patients suffering from refractory cardiogenic shock. Thromboembolic complications (TeC) are common in VA-ECMO patients and are associated with increased morbidity and mortality. Valid markers to predict TeC in VA-ECMO patients are lacking. The present study investigated the predictive value of baseline Fibrinogen–Albumin-Ratio (FAR) for in-hospital TeC in patients undergoing VA-ECMO. This retrospective cohort study included patients who underwent VA-ECMO therapy due to cardiogenic shock at the University Hospital Duesseldorf, Germany between 2011 and 2018. Main exposure was baseline FAR measured at initiation of VA-ECMO therapy. The primary endpoint was the in-hospital incidence of TeC. In total, 344 patients were included into analysis (74.7% male, mean age 59 ± 14 years). The in-hospital incidence of TeC was 34%. Receiver operating characteristics (ROC) curve of FAR for in-hospital TeC revealed an area under the curve of 0.67 [95% confidence interval (CI) 0.61–0.74]. Youden index determined a cutoff of 130 for baseline FAR. Multivariate logistic regression revealed an adjusted odds-ratio of 3.72 [95% CI 2.26–6.14] for the association between FAR and TeC. Baseline FAR is independently associated with in-hospital TeC in patients undergoing VA-ECMO. Thus, FAR might contribute to the prediction of TeC in this cohort.
format	article
author	Sebastian Roth Catrin Jansen René M’Pembele Alexandra Stroda Udo Boeken Payam Akhyari Artur Lichtenberg Markus W. Hollmann Ragnar Huhn Giovanna Lurati Buse Hug Aubin
author_facet	Sebastian Roth Catrin Jansen René M’Pembele Alexandra Stroda Udo Boeken Payam Akhyari Artur Lichtenberg Markus W. Hollmann Ragnar Huhn Giovanna Lurati Buse Hug Aubin
author_sort	Sebastian Roth
title	Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
title_short	Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
title_full	Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
title_fullStr	Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
title_full_unstemmed	Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO
title_sort	fibrinogen–albumin-ratio is an independent predictor of thromboembolic complications in patients undergoing va-ecmo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/780f78bfb91b46618d6293c692855c00
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Fibrinogen–Albumin-Ratio is an independent predictor of thromboembolic complications in patients undergoing VA-ECMO

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