Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma

Shen Shen,1,2 Yanfang Wang3 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 2Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou,...

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Autores principales:	Shen S, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	e2f2 hepatocellular carcinoma prognosis hub genes diagnosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/780fa5bd26a64f87998f4d700f6e5023
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spelling	oai:doaj.org-article:780fa5bd26a64f87998f4d700f6e50232021-11-18T19:40:25ZExpression and Prognostic Role of E2F2 in Hepatocellular Carcinoma1178-7074https://doaj.org/article/780fa5bd26a64f87998f4d700f6e50232021-11-01T00:00:00Zhttps://www.dovepress.com/expression-and-prognostic-role-of-e2f2-in-hepatocellular-carcinoma-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Shen Shen,1,2 Yanfang Wang3 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 2Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China; 3Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of ChinaCorrespondence: Shen ShenGene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, People’s Republic of ChinaEmail fccshenk@zzu.edu.cnIntroduction: Hepatocellular carcinoma (HCC) is a common clinical malignancy. Recent studies reported that E2F transcription factor 2 (E2F2) plays a significant role in tumor progression. However, its expression and biological function in HCC are still unclear. Therefore, we explored the relationship between E2F2 expression and tumor progression in HCC.Methods: In this study, we utilized some online tools to explore the E2F2 expression in pan-carcinoma and HCC. The association of E2F2 expression with the clinical characteristics and prognosis of HCC was further studied. In addition, we explored the co-expressed genes of E2F2 and mined the positively/negatively corrected significant genes and excavated the possible functions. Meanwhile, the hub gene set was constructed based on protein–protein interaction (PPI) network, and the relationship between E2F2 and immunity was discovered.Results: We observed that the expression level of E2F2 was generally upregulated in HCC. However, E2F2 expression was not significantly different between HCC and normal tissues in regard to the disease stage 4. Furthermore, we also observed the poor prognosis in patients with high E2F2 expression. The co-expressed genes of E2F2 were identified and further detected. Thereafter, we identified the positively/negatively corrected significant genes and constructed the hub gene network of E2F2 based on PPI network. We also found that E2F2 expression was positively correlated with the infiltration levels of CD4+ T, CD8+ T cells, macrophages, neutrophils, and dendritic cells.Conclusion: Our findings suggested that E2F2 could be a potential prognostic factor for HCC, which could provide a therapeutic target for the molecular treatment of HCC.Keywords: E2F2, hepatocellular carcinoma, prognosis, hub genes, diagnosisShen SWang YDove Medical Pressarticlee2f2hepatocellular carcinomaprognosishub genesdiagnosisMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8463-8472 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	e2f2 hepatocellular carcinoma prognosis hub genes diagnosis Medicine (General) R5-920
spellingShingle	e2f2 hepatocellular carcinoma prognosis hub genes diagnosis Medicine (General) R5-920 Shen S Wang Y Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma
description	Shen Shen,1,2 Yanfang Wang3 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 2Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China; 3Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of ChinaCorrespondence: Shen ShenGene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, People’s Republic of ChinaEmail fccshenk@zzu.edu.cnIntroduction: Hepatocellular carcinoma (HCC) is a common clinical malignancy. Recent studies reported that E2F transcription factor 2 (E2F2) plays a significant role in tumor progression. However, its expression and biological function in HCC are still unclear. Therefore, we explored the relationship between E2F2 expression and tumor progression in HCC.Methods: In this study, we utilized some online tools to explore the E2F2 expression in pan-carcinoma and HCC. The association of E2F2 expression with the clinical characteristics and prognosis of HCC was further studied. In addition, we explored the co-expressed genes of E2F2 and mined the positively/negatively corrected significant genes and excavated the possible functions. Meanwhile, the hub gene set was constructed based on protein–protein interaction (PPI) network, and the relationship between E2F2 and immunity was discovered.Results: We observed that the expression level of E2F2 was generally upregulated in HCC. However, E2F2 expression was not significantly different between HCC and normal tissues in regard to the disease stage 4. Furthermore, we also observed the poor prognosis in patients with high E2F2 expression. The co-expressed genes of E2F2 were identified and further detected. Thereafter, we identified the positively/negatively corrected significant genes and constructed the hub gene network of E2F2 based on PPI network. We also found that E2F2 expression was positively correlated with the infiltration levels of CD4+ T, CD8+ T cells, macrophages, neutrophils, and dendritic cells.Conclusion: Our findings suggested that E2F2 could be a potential prognostic factor for HCC, which could provide a therapeutic target for the molecular treatment of HCC.Keywords: E2F2, hepatocellular carcinoma, prognosis, hub genes, diagnosis
format	article
author	Shen S Wang Y
author_facet	Shen S Wang Y
author_sort	Shen S
title	Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma
title_short	Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma
title_full	Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma
title_fullStr	Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma
title_full_unstemmed	Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma
title_sort	expression and prognostic role of e2f2 in hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/780fa5bd26a64f87998f4d700f6e5023
work_keys_str_mv	AT shens expressionandprognosticroleofe2f2inhepatocellularcarcinoma AT wangy expressionandprognosticroleofe2f2inhepatocellularcarcinoma
_version_	1718420735782813696

Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma

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