The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.

As humans age, they experience a progressive loss of thymic function and a corresponding shift in the makeup of the circulating CD8+ T cell population from naïve to memory phenotype. These alterations are believed to result in impaired CD8+ T cell responses in older individuals; however, evidence th...

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Autores principales:	Alina Lelic, Chris P Verschoor, Mario Ventresca, Robin Parsons, Carole Evelegh, Dawn Bowdish, Michael R Betts, Mark B Loeb, Jonathan L Bramson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/78113a49ab524d1784921b895d90b156
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spelling	oai:doaj.org-article:78113a49ab524d1784921b895d90b1562021-11-18T06:06:15ZThe polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.1553-73661553-737410.1371/journal.ppat.1003076https://doaj.org/article/78113a49ab524d1784921b895d90b1562012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23271970/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374As humans age, they experience a progressive loss of thymic function and a corresponding shift in the makeup of the circulating CD8+ T cell population from naïve to memory phenotype. These alterations are believed to result in impaired CD8+ T cell responses in older individuals; however, evidence that these global changes impact virus-specific CD8+ T cell immunity in the elderly is lacking. To gain further insight into the functionality of virus-specific CD8+ T cells in older individuals, we interrogated a cohort of individuals who were acutely infected with West Nile virus (WNV) and chronically infected with Epstein Barr virus (EBV) and Cytomegalovirus (CMV). The cohort was stratified into young (<40 yrs), middle-aged (41-59 yrs) and aged (>60 yrs) groups. In the aged cohort, the CD8+ T cell compartment displayed a marked reduction in the frequency of naïve CD8+ T cells and increased frequencies of CD8+ T cells that expressed CD57 and lacked CD28, as previously described. However, we did not observe an influence of age on either the frequency of virus-specific CD8+ T cells within the circulating pool nor their functionality (based on the production of IFNγ, TNFα, IL2, Granzyme B, Perforin and mobilization of CD107a). We did note that CD8+ T cells specific for WNV, CMV or EBV displayed distinct functional profiles, but these differences were unrelated to age. Collectively, these data fail to support the hypothesis that immunosenescence leads to defective CD8+ T cell immunity and suggest that it should be possible to develop CD8+ T cell vaccines to protect aged individuals from infections with novel emerging viruses.Alina LelicChris P VerschoorMario VentrescaRobin ParsonsCarole EveleghDawn BowdishMichael R BettsMark B LoebJonathan L BramsonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 12, p e1003076 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Alina Lelic Chris P Verschoor Mario Ventresca Robin Parsons Carole Evelegh Dawn Bowdish Michael R Betts Mark B Loeb Jonathan L Bramson The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.
description	As humans age, they experience a progressive loss of thymic function and a corresponding shift in the makeup of the circulating CD8+ T cell population from naïve to memory phenotype. These alterations are believed to result in impaired CD8+ T cell responses in older individuals; however, evidence that these global changes impact virus-specific CD8+ T cell immunity in the elderly is lacking. To gain further insight into the functionality of virus-specific CD8+ T cells in older individuals, we interrogated a cohort of individuals who were acutely infected with West Nile virus (WNV) and chronically infected with Epstein Barr virus (EBV) and Cytomegalovirus (CMV). The cohort was stratified into young (<40 yrs), middle-aged (41-59 yrs) and aged (>60 yrs) groups. In the aged cohort, the CD8+ T cell compartment displayed a marked reduction in the frequency of naïve CD8+ T cells and increased frequencies of CD8+ T cells that expressed CD57 and lacked CD28, as previously described. However, we did not observe an influence of age on either the frequency of virus-specific CD8+ T cells within the circulating pool nor their functionality (based on the production of IFNγ, TNFα, IL2, Granzyme B, Perforin and mobilization of CD107a). We did note that CD8+ T cells specific for WNV, CMV or EBV displayed distinct functional profiles, but these differences were unrelated to age. Collectively, these data fail to support the hypothesis that immunosenescence leads to defective CD8+ T cell immunity and suggest that it should be possible to develop CD8+ T cell vaccines to protect aged individuals from infections with novel emerging viruses.
format	article
author	Alina Lelic Chris P Verschoor Mario Ventresca Robin Parsons Carole Evelegh Dawn Bowdish Michael R Betts Mark B Loeb Jonathan L Bramson
author_facet	Alina Lelic Chris P Verschoor Mario Ventresca Robin Parsons Carole Evelegh Dawn Bowdish Michael R Betts Mark B Loeb Jonathan L Bramson
author_sort	Alina Lelic
title	The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.
title_short	The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.
title_full	The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.
title_fullStr	The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.
title_full_unstemmed	The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.
title_sort	polyfunctionality of human memory cd8+ t cells elicited by acute and chronic virus infections is not influenced by age.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/78113a49ab524d1784921b895d90b156
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The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.

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