DENV inhibits type I IFN production in infected cells by cleaving human STING.

DENV inhibits type I IFN production in infected cells by cleaving human STING.

Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a wide range of cells involved in the immune response. To efficiently infect humans, DENV must evade or inhibit fundamental elements of the innate immune system, namely the type I interferon response. DENV circumv...

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Autores principales: Sebastian Aguirre, Ana M Maestre, Sarah Pagni, Jenish R Patel, Timothy Savage, Delia Gutman, Kevin Maringer, Dabeiba Bernal-Rubio, Reed S Shabman, Viviana Simon, Juan R Rodriguez-Madoz, Lubbertus C F Mulder, Glen N Barber, Ana Fernandez-Sesma
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/78139064b4bc4ba996ad45f43d5b6e8a
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