Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins

Hironobu Koseki,1 Tomohiko Asahara,1 Takayuki Shida,1 Itaru Yoda,1 Hidehiko Horiuchi,1 Koumei Baba,2 Makoto Osaki11Department of Orthopedic Surgery, Graduate School of Medicine, Nagasaki University, 2Industrial Technology Center of Nagasaki, Nagasaki, JapanBackground: Pin site infection is the most...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koseki H, Asahara T, Shida T, Yoda I, Horiuchi H, Baba K, Osaki M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/78150c9d9b584ce19ba0681980660b86
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:78150c9d9b584ce19ba0681980660b86
record_format	dspace
spelling	oai:doaj.org-article:78150c9d9b584ce19ba0681980660b862021-12-02T02:01:53ZClinical and histomorphometrical study on titanium dioxide-coated external fixation pins1176-91141178-2013https://doaj.org/article/78150c9d9b584ce19ba0681980660b862013-02-01T00:00:00Zhttp://www.dovepress.com/clinical-and-histomorphometrical-study-on-titanium-dioxide-coated-exte-a12135https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hironobu Koseki,1 Tomohiko Asahara,1 Takayuki Shida,1 Itaru Yoda,1 Hidehiko Horiuchi,1 Koumei Baba,2 Makoto Osaki11Department of Orthopedic Surgery, Graduate School of Medicine, Nagasaki University, 2Industrial Technology Center of Nagasaki, Nagasaki, JapanBackground: Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO2) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study.Methods: Pins contaminated with an identifiable Staphylococcus aureus strain were inserted into femoral bone in a rat model and exposed to ultraviolet A light for 30 minutes. On day 14, the animals were sacrificed and the bone and soft tissue around the pin were retrieved. The clinical findings and histological findings were evaluated in 60 samples.Results: Clinical signs of infection were present in 76.7% of untreated pins, but in only 36.7% of TiO2-coated pins. The histological bone infection score and planimetric rate of occupation for bacterial colonies and neutrophils in the TiO2-coated pin group were lower than those in the control group. The bone-implant contact ratio of the TiO2-coated pin group was significantly higher (71.4%) than in the control pin group (58.2%). The TiO2 was successful in decreasing infection both clinically and histomorphometrically.Conclusion: The photocatalytic bactericidal effect of TiO2 is thought to be useful for inhibiting pin site infection after external fixation.Keywords: titanium dioxide, external fixation, bactericidal activity, Staphylococcus aureusKoseki HAsahara TShida TYoda IHoriuchi HBaba KOsaki MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 593-599 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Koseki H Asahara T Shida T Yoda I Horiuchi H Baba K Osaki M Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
description	Hironobu Koseki,1 Tomohiko Asahara,1 Takayuki Shida,1 Itaru Yoda,1 Hidehiko Horiuchi,1 Koumei Baba,2 Makoto Osaki11Department of Orthopedic Surgery, Graduate School of Medicine, Nagasaki University, 2Industrial Technology Center of Nagasaki, Nagasaki, JapanBackground: Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO2) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study.Methods: Pins contaminated with an identifiable Staphylococcus aureus strain were inserted into femoral bone in a rat model and exposed to ultraviolet A light for 30 minutes. On day 14, the animals were sacrificed and the bone and soft tissue around the pin were retrieved. The clinical findings and histological findings were evaluated in 60 samples.Results: Clinical signs of infection were present in 76.7% of untreated pins, but in only 36.7% of TiO2-coated pins. The histological bone infection score and planimetric rate of occupation for bacterial colonies and neutrophils in the TiO2-coated pin group were lower than those in the control group. The bone-implant contact ratio of the TiO2-coated pin group was significantly higher (71.4%) than in the control pin group (58.2%). The TiO2 was successful in decreasing infection both clinically and histomorphometrically.Conclusion: The photocatalytic bactericidal effect of TiO2 is thought to be useful for inhibiting pin site infection after external fixation.Keywords: titanium dioxide, external fixation, bactericidal activity, Staphylococcus aureus
format	article
author	Koseki H Asahara T Shida T Yoda I Horiuchi H Baba K Osaki M
author_facet	Koseki H Asahara T Shida T Yoda I Horiuchi H Baba K Osaki M
author_sort	Koseki H
title	Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
title_short	Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
title_full	Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
title_fullStr	Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
title_full_unstemmed	Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
title_sort	clinical and histomorphometrical study on titanium dioxide-coated external fixation pins
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/78150c9d9b584ce19ba0681980660b86
work_keys_str_mv	AT kosekih clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins AT asaharat clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins AT shidat clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins AT yodai clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins AT horiuchih clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins AT babak clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins AT osakim clinicalandhistomorphometricalstudyontitaniumdioxidecoatedexternalfixationpins
_version_	1718402785243824128

Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins

Ejemplares similares