CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)

Abstract. This section of our review article deals with prevalence, genetic factors, and some immune mechanisms of chronic urticaria in children. In any form of chronic urticaria, the main pathogenetic role is ascribed to mast cells and basophiles. Increased production of cyto- and chemokines, e.g.,...

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Autores principales:	N. A. Sinelnikova, N. M. Kalinina, N. D. Savenkova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic urticaria cytokines basophils cd203c Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7818e632f5454a198e9a059f55233960
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spelling	oai:doaj.org-article:7818e632f5454a198e9a059f552339602021-11-18T08:03:43ZCHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)1563-06252313-741X10.15789/1563-0625-2013-3-203-214https://doaj.org/article/7818e632f5454a198e9a059f552339602014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/625https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. This section of our review article deals with prevalence, genetic factors, and some immune mechanisms of chronic urticaria in children. In any form of chronic urticaria, the main pathogenetic role is ascribed to mast cells and basophiles. Increased production of cyto- and chemokines, e.g., CCL2, CХCL8, IL-1, IL-4, IL-6, IL-10, IL-13, IL-17, is observed during chronic inflammatory reactions typical to this disease. Activation of mast cells and basophiles proceeds via specific receptors on the target cell membranes. Autoimmune urticaria is of special importance. In this disorder, autoantibodies are directed against IgE or FCεRIα, thus causing histamine release, due to cross-linking of α-chains of high-affinity IgE receptor, or binding of IgE fixed on the mast cells. Degranulation of basophils is followed by occurrence of activation molecules (СD203с, CD63). Some workers presumet that association between СD203с expression and positive autologous serum skin test may be a sign of autoimmune process. Increased expression of CD40L ligand on the surface of activated T cells suggests enhanced signaling for B cell activation and production of autoantibodies.N. A. SinelnikovaN. M. KalininaN. D. SavenkovaSPb RAACIarticlechronic urticariacytokinesbasophilscd203cImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 3, Pp 203-214 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic urticaria cytokines basophils cd203c Immunologic diseases. Allergy RC581-607
spellingShingle	chronic urticaria cytokines basophils cd203c Immunologic diseases. Allergy RC581-607 N. A. Sinelnikova N. M. Kalinina N. D. Savenkova CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)
description	Abstract. This section of our review article deals with prevalence, genetic factors, and some immune mechanisms of chronic urticaria in children. In any form of chronic urticaria, the main pathogenetic role is ascribed to mast cells and basophiles. Increased production of cyto- and chemokines, e.g., CCL2, CХCL8, IL-1, IL-4, IL-6, IL-10, IL-13, IL-17, is observed during chronic inflammatory reactions typical to this disease. Activation of mast cells and basophiles proceeds via specific receptors on the target cell membranes. Autoimmune urticaria is of special importance. In this disorder, autoantibodies are directed against IgE or FCεRIα, thus causing histamine release, due to cross-linking of α-chains of high-affinity IgE receptor, or binding of IgE fixed on the mast cells. Degranulation of basophils is followed by occurrence of activation molecules (СD203с, CD63). Some workers presumet that association between СD203с expression and positive autologous serum skin test may be a sign of autoimmune process. Increased expression of CD40L ligand on the surface of activated T cells suggests enhanced signaling for B cell activation and production of autoantibodies.
format	article
author	N. A. Sinelnikova N. M. Kalinina N. D. Savenkova
author_facet	N. A. Sinelnikova N. M. Kalinina N. D. Savenkova
author_sort	N. A. Sinelnikova
title	CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)
title_short	CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)
title_full	CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)
title_fullStr	CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)
title_full_unstemmed	CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)
title_sort	chronic urticarial in childhood. immune pathology of chronic urticarial in children (part i)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7818e632f5454a198e9a059f55233960
work_keys_str_mv	AT nasinelnikova chronicurticarialinchildhoodimmunepathologyofchronicurticarialinchildrenparti AT nmkalinina chronicurticarialinchildhoodimmunepathologyofchronicurticarialinchildrenparti AT ndsavenkova chronicurticarialinchildhoodimmunepathologyofchronicurticarialinchildrenparti
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CHRONIC URTICARIAL IN CHILDHOOD. IMMUNE PATHOLOGY OF CHRONIC URTICARIAL IN CHILDREN (PART I)

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