Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma
BackgroundPattern recognition receptors (PRRs) family plays a vital role in the initial stage of innate immune response and the subsequent activation of adaptive immunity. Increasing evidences have indicated that several PRRs play critical roles in the progress of inflammation and tumorigenesis. How...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:781fe5e2d11343c2a95069fdf59f36c82021-11-09T06:09:36ZPattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma1664-322410.3389/fimmu.2021.765615https://doaj.org/article/781fe5e2d11343c2a95069fdf59f36c82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.765615/fullhttps://doaj.org/toc/1664-3224BackgroundPattern recognition receptors (PRRs) family plays a vital role in the initial stage of innate immune response and the subsequent activation of adaptive immunity. Increasing evidences have indicated that several PRRs play critical roles in the progress of inflammation and tumorigenesis. However, the comprehensive significance of PRRs family in clinical prognosis of different cancers is still elusive.MethodsWe analyzed expression of 20 canonical PRRs in tumor samples from 9502 patients of 33 tumor types. Next, we used expression profiles of PRRs in skin cutaneous melanoma (SKCM) to build a Cox prognosis model. Then, we analyzed immune infiltration features and immune activity of high risk score and low risk score patients. Finally, we analyzed the single-cell sequencing data of different cancers and detected the expression of PRRs in mouse melanoma model to identify PRRs-expressing cell types.ResultsWe found PRRs had a significantly positive correlation with prognosis in SKCM rather than other tumors, and PRR-based Cox model had a much better prognosis potential than any single PRR. Further analysis shows risk score could indicate immunocyte infiltration and immune activity in SKCM. We also found the expressions of some PRR genes were highly correlated with the expression of immune checkpoints molecules in SKCM, indicating they could be indicators for clinical immune therapy. Finally, we found only in SKCM samples, the expression of PRRs is especially high in a subpopulation of macrophages with a trait of CD206 low expression, probably explaining why PRRs have prognosis potential in melanoma.ConclusionsOur study reveals PRR family in macrophages has a positive prognosis potential in melanoma and could be valuable for clinical prognosis and immune therapy.Qihang ZhaoQiang WangTengjiao WangJunfang XuJunfang XuTingting LiQiuyan LiuQinghua YaoQinghua YaoPin WangFrontiers Media S.A.articlepattern recognition receptorsskin cutaneous melanomaprognosisimmune-infiltrationmacrophageImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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pattern recognition receptors skin cutaneous melanoma prognosis immune-infiltration macrophage Immunologic diseases. Allergy RC581-607 |
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pattern recognition receptors skin cutaneous melanoma prognosis immune-infiltration macrophage Immunologic diseases. Allergy RC581-607 Qihang Zhao Qiang Wang Tengjiao Wang Junfang Xu Junfang Xu Tingting Li Qiuyan Liu Qinghua Yao Qinghua Yao Pin Wang Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma |
| description |
BackgroundPattern recognition receptors (PRRs) family plays a vital role in the initial stage of innate immune response and the subsequent activation of adaptive immunity. Increasing evidences have indicated that several PRRs play critical roles in the progress of inflammation and tumorigenesis. However, the comprehensive significance of PRRs family in clinical prognosis of different cancers is still elusive.MethodsWe analyzed expression of 20 canonical PRRs in tumor samples from 9502 patients of 33 tumor types. Next, we used expression profiles of PRRs in skin cutaneous melanoma (SKCM) to build a Cox prognosis model. Then, we analyzed immune infiltration features and immune activity of high risk score and low risk score patients. Finally, we analyzed the single-cell sequencing data of different cancers and detected the expression of PRRs in mouse melanoma model to identify PRRs-expressing cell types.ResultsWe found PRRs had a significantly positive correlation with prognosis in SKCM rather than other tumors, and PRR-based Cox model had a much better prognosis potential than any single PRR. Further analysis shows risk score could indicate immunocyte infiltration and immune activity in SKCM. We also found the expressions of some PRR genes were highly correlated with the expression of immune checkpoints molecules in SKCM, indicating they could be indicators for clinical immune therapy. Finally, we found only in SKCM samples, the expression of PRRs is especially high in a subpopulation of macrophages with a trait of CD206 low expression, probably explaining why PRRs have prognosis potential in melanoma.ConclusionsOur study reveals PRR family in macrophages has a positive prognosis potential in melanoma and could be valuable for clinical prognosis and immune therapy. |
| format |
article |
| author |
Qihang Zhao Qiang Wang Tengjiao Wang Junfang Xu Junfang Xu Tingting Li Qiuyan Liu Qinghua Yao Qinghua Yao Pin Wang |
| author_facet |
Qihang Zhao Qiang Wang Tengjiao Wang Junfang Xu Junfang Xu Tingting Li Qiuyan Liu Qinghua Yao Qinghua Yao Pin Wang |
| author_sort |
Qihang Zhao |
| title |
Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma |
| title_short |
Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma |
| title_full |
Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma |
| title_fullStr |
Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma |
| title_full_unstemmed |
Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma |
| title_sort |
pattern recognition receptors (prrs) in macrophages possess prognosis and immunotherapy potential for melanoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/781fe5e2d11343c2a95069fdf59f36c8 |
| work_keys_str_mv |
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